Palladium-Catalyzed Desymmetric Intermolecular C-N Coupling Enabled by a Chiral Monophosphine Ligand Derived from Anthracene Photodimer

被引：11

作者：

Wang, Xin ^{[1
]}

Liu, Wei-Gang ^{[1
]}

Liu, Lan-Tao ^{[2
]}

Yang, Xiao-Di ^{[3
]}

Niu, Shu ^{[1
]}

Tung, Chen-Ho ^{[1
]}

Wu, Li-Zhu ^{[1
]}

Cong, Huan ^{[1
]}

机构：

[1] Chinese Acad Sci, Univ Chinese Acad Sci, Sch Future Technol, Tech Inst Phys & Chem,Key Lab Photochem Convers &, Beijing 100190, Peoples R China

[2] Shangqiu Normal Univ, Coll Chem & Chem Engn, Shangqiu 476000, Henan, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Res Ctr Chiral Drugs, Innovat Res Inst Tradit Chinese Med, Shanghai 200438, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 14期

基金：

中国国家自然科学基金;

关键词：

LONG-LIVED CATALYSTS; ENANTIOSELECTIVE SYNTHESIS; ARYL CHLORIDES; DERIVATIVES; AMINATION; HETEROARYL; ARYLATION; BINOL; INSIGHTS; TADDOLS;

D O I：

10.1021/acs.orglett.1c01839

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of chiral ligands with privileged scaffolds plays an important role in transition-metal-catalyzed asymmetric reactions. Herein we present anthracene-photodimer-derived chiral monophosphine ligand 1, which features dual chirality and a rigid scaffold. This ligand exhibits remarkable efficiency in Pd-catalyzed desymmetric intermolecular C-N coupling under mild conditions with excellent chemo- and enantioselectivity.

引用

收藏

页码：5485 / 5490

页数：6

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