Palladium-Catalyzed Desymmetric Intermolecular C-N Coupling Enabled by a Chiral Monophosphine Ligand Derived from Anthracene Photodimer

被引:11
作者
Wang, Xin [1 ]
Liu, Wei-Gang [1 ]
Liu, Lan-Tao [2 ]
Yang, Xiao-Di [3 ]
Niu, Shu [1 ]
Tung, Chen-Ho [1 ]
Wu, Li-Zhu [1 ]
Cong, Huan [1 ]
机构
[1] Chinese Acad Sci, Univ Chinese Acad Sci, Sch Future Technol, Tech Inst Phys & Chem,Key Lab Photochem Convers &, Beijing 100190, Peoples R China
[2] Shangqiu Normal Univ, Coll Chem & Chem Engn, Shangqiu 476000, Henan, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Res Ctr Chiral Drugs, Innovat Res Inst Tradit Chinese Med, Shanghai 200438, Peoples R China
基金
中国国家自然科学基金;
关键词
LONG-LIVED CATALYSTS; ENANTIOSELECTIVE SYNTHESIS; ARYL CHLORIDES; DERIVATIVES; AMINATION; HETEROARYL; ARYLATION; BINOL; INSIGHTS; TADDOLS;
D O I
10.1021/acs.orglett.1c01839
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The development of chiral ligands with privileged scaffolds plays an important role in transition-metal-catalyzed asymmetric reactions. Herein we present anthracene-photodimer-derived chiral monophosphine ligand 1, which features dual chirality and a rigid scaffold. This ligand exhibits remarkable efficiency in Pd-catalyzed desymmetric intermolecular C-N coupling under mild conditions with excellent chemo- and enantioselectivity.
引用
收藏
页码:5485 / 5490
页数:6
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