Non-Exosomal and Exosomal Circulatory MicroRNAs: Which Are More Valid as Biomarkers?

被引：156

作者：

Kamal, Nik Nur Syazana Binti Nik Mohamed ^{[1
]}

Shahidan, Wan Nazatul Shima ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Dent Sci, Craniofacial Sci Lab, Hlth Campus, Kubang Kerian, Malaysia

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 10卷

关键词：

exosome; miRNA; biomarker; body fluid; non-exosomal; PLASMA-MEMBRANE; EXTRACELLULAR VESICLES; APOPTOTIC CELLS; PLATELET MICROPARTICLES; CLINICAL-SIGNIFICANCE; TRANSFERRIN RECEPTOR; THERAPEUTIC TARGETS; STRUCTURAL BASIS; SERUM; CANCER;

D O I：

10.3389/fphar.2019.01500

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

MicroRNAs (miRNAs) are a group of small non-coding RNAs with approximately 19-25 nucleotides that are involved in regulating a range of developmental and physiological processes. Non-exosomal circulating and exosomal miRNAs have also been proposed to be useful in diagnostics as biomarkers for diseases and different types of cancer. In this review, the quantity of miRNAs and of reliable experimental data analyses of miRNAs that come from exosomal and non-exosomal sources are discussed from the perspective of their use as biomarkers for cancer and other diseases, including viral infections, nervous system disorders, cardiovascular disorders, and diabetes. We summarize other research findings regarding the use of miRNA from these two sources as biomarkers in diagnostics and clinical use. The challenges in using miRNA from these two sources in cancer and disease diagnostics are evaluated and discussed. Validation of specific miRNA signatures as biomarkers is a critical milestone in diagnostics.

引用

页数：22

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