Straightforward Synthesis of Enantiopure 2,3-Dihydrobenzofurans by a Sequential Stereoselective Biotransformation and Chemical Intramolecular Cyclization

被引：43

作者：

Mangas-Sanchez, Juan ^{[1
]}

Busto, Eduardo ^{[1
]}

Gotor-Fernandez, Vicente ^{[1
]}

Gotor, Vicente ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Biotecnol Asturias, Dept Quim Organ & Inorgan, E-33006 Oviedo, Spain

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 15期

关键词：

ASYMMETRIC INDUCTION; COMBINATION; ANALOGS; ETHERS;

D O I：

10.1021/ol101336y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new family of optically active 2,3-dihydrobenzofurans has been prepared by a simple chemoenzymatic asymmetric strategy. This synthetic approach is based on the combination of a lipase-mediated kinetic resolution of 1-aryl-2-propanols or bioreduction of the corresponding ketones followed by an intramolecular cyclization reaction. These novel compounds have been prepared in enantiopure form and in good overall yield through a straightforward route.

引用

页码：3498 / 3501

页数：4

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