Mapping Coexistence Phase Diagrams of Block Copolymer Micelles and Free Unimer Chains
被引:13
作者:
Li, Xiuli
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA
Virginia Tech, Macromol Innovat Inst, Blacksburg, VA 24061 USAVirginia Tech, Dept Chem, Blacksburg, VA 24061 USA
Li, Xiuli
[1
,2
]
Cooksey, Tyler J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Houston, Dept Chem & Biomol Engn, Houston, TX 77004 USAVirginia Tech, Dept Chem, Blacksburg, VA 24061 USA
Cooksey, Tyler J.
[3
]
Kidd, Bryce E.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA
Virginia Tech, Macromol Innovat Inst, Blacksburg, VA 24061 USAVirginia Tech, Dept Chem, Blacksburg, VA 24061 USA
Kidd, Bryce E.
[1
,2
]
Robertson, Megan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Houston, Dept Chem & Biomol Engn, Houston, TX 77004 USAVirginia Tech, Dept Chem, Blacksburg, VA 24061 USA
Robertson, Megan L.
[3
]
Madsen, Louis A.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA
Virginia Tech, Macromol Innovat Inst, Blacksburg, VA 24061 USAVirginia Tech, Dept Chem, Blacksburg, VA 24061 USA
Madsen, Louis A.
[1
,2
]
机构:
[1] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA
[2] Virginia Tech, Macromol Innovat Inst, Blacksburg, VA 24061 USA
Block copolymer micelles can carry molecular cargo in a nanoscopic package that is tunable via polymer structure in combination with cargo and/or solution properties. We use NMR spectroscopy and diffusometry to investigate spherical micelles that self-assemble from diblock poly(ethylene oxide)-b-(epsilon-caprolactone) (PEO-PCL) at 1% w/v in D2O-THF-d(8) mixed solvents. For two series of micelles with block masses of 2 and 3 kg/mol (PEO and PCL, respectively) and 5 and 8 kg/ mol, we quantify diffusion coefficients and relative populations of micelles and free unimers over a range of temperatures (21-50 degrees C) and solvent compositions (10-100 vol % THF-d(8)). Micelles and free unimers coexist over surprisingly large areas of these micelle-unimer phase diagrams and with a large variation of relative populations. This study provides a new avenue for understanding how inter- and intramolecular interactions fundamentally affect unimer exchange, cargo release, the thermodynamics of chain partitioning, and the tuning of micelle structure and dynamics.
机构:
Univ Nebraska, Med Ctr, Coll Pharm, Dept Pharmaceut Sci,Ctr Drug Delivery & Nanomed, Omaha, NE 68198 USAUniv Nebraska, Med Ctr, Coll Pharm, Dept Pharmaceut Sci,Ctr Drug Delivery & Nanomed, Omaha, NE 68198 USA
Batrakova, Elena V.
;
Kabanov, Alexander V.
论文数: 0引用数: 0
h-index: 0
机构:
Moscow MV Lomonosov State Univ, Dept Chem, Moscow, RussiaUniv Nebraska, Med Ctr, Coll Pharm, Dept Pharmaceut Sci,Ctr Drug Delivery & Nanomed, Omaha, NE 68198 USA
机构:
Univ Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan
Cabral, Horacio
;
Kataoka, Kazunori
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Grad Sch Engn, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Grad Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138654, JapanUniv Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan
机构:
Univ Nebraska, Med Ctr, Coll Pharm, Dept Pharmaceut Sci,Ctr Drug Delivery & Nanomed, Omaha, NE 68198 USAUniv Nebraska, Med Ctr, Coll Pharm, Dept Pharmaceut Sci,Ctr Drug Delivery & Nanomed, Omaha, NE 68198 USA
Batrakova, Elena V.
;
Kabanov, Alexander V.
论文数: 0引用数: 0
h-index: 0
机构:
Moscow MV Lomonosov State Univ, Dept Chem, Moscow, RussiaUniv Nebraska, Med Ctr, Coll Pharm, Dept Pharmaceut Sci,Ctr Drug Delivery & Nanomed, Omaha, NE 68198 USA
机构:
Univ Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, JapanUniv Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan
Cabral, Horacio
;
Kataoka, Kazunori
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Grad Sch Engn, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1138656, Japan
Univ Tokyo, Grad Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138654, JapanUniv Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan