The Impact of Angiotensin-Converting Enzyme Gene on Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease

被引：4
|
作者：
Hsieh, Sun-Wung [1 ,2 ,3 ]
Liu, Ming-Wei [4 ]
Huang, Ling-Chun [2 ,3 ,5 ]
Wu, Meng-Ni [2 ,3 ]
Yang, Yuan-Han [2 ,3 ,5 ,6 ,7 ]
机构：
[1] Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Neurol, Kaohsiung, Taiwan
[2] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung, Taiwan
[3] Kaohsiung Med Univ, Neurosci Res Ctr, Kaohsiung, Taiwan
[4] Cathay Gen Hosp, Dept Surg, Taipei, Taiwan
[5] Kaohsiung Med Univ Hosp, Kaohsiung Municipal Ta Tung Hosp, Dept Neurol, Kaohsiung, Taiwan
[6] Kaohsiung Med Univ, Fac Med, Dept & Masters Program Neurol, Kaohsiung, Taiwan
[7] Chinese Mental Protect Assoc, Kaohsiung, Taiwan
来源：
CURRENT ALZHEIMER RESEARCH | 2019年 / 16卷 / 14期
关键词：
Alzheimer's disease; angiotensin-converting enzyme gene; apolipoprotein E gene; behavioral and psychological symptoms of dementia; neuropsychiatric inventory; beta-amyloid; INSERTION-DELETION POLYMORPHISM; CORTICAL WHITE-MATTER; AMYLOID-BETA; TEMPORAL CORTEX; E GENOTYPE; BRAIN; ACE; RISK; ASSOCIATION; INHIBITORS;
D O I：
10.2174/1567205017666200103114550
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: The Angiotensin-Converting Enzyme (ACE) gene has drawn attention for its possible role in regulating the degradation of beta-amyloid (A beta), yet its role in affecting the cognitive and psychiatric symptoms of Alzheimer's Disease (AD) patients has yet to be elucidated. Objective: This study aimed to investigate whether the ACE gene acts as a risk factor of Behavioral and Psychological Symptoms of Dementia (BPSD) in the AD population. Methods: The genotyping of ACE and Apolipoprotein E gene with allele epsilon 4(APOE epsilon 4) was determined among 360s clinically diagnosed AD patients. Symptoms and severity of BPSD were evaluated annually via Neuropsychiatric Inventory (NPI). Results: At the base measurement of the first year of patient recruitment, there were no significant con- tributory risk factors to NPI score. In the two-year follow-up, ACE insertion polymorphism showed a significant risk (adjusted odds ratio 1.65, 95% CI=1.1- 2.5, p=0.019) of progression of NPI total score. Conclusion: ACE gene is involved in aggravating BPSD among AD patients.
引用
收藏
页码：1269 / 1275
页数：7
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