Reusable Nano-Zirconia-Catalyzed Synthesis of Benzimidazoles and Their Antibacterial and Antifungal Activities

被引：13

作者：

Rao, Tentu Nageswara ^{[1
]}

AlOmar, Suliman Yousef ^{[2
]}

Ahmed, Faheem ^{[3
]}

Albalawi, Fadwa ^{[2
]}

Ahmad, Naushad ^{[4
]}

Rao, Nalla Krishna ^{[5
]}

Rao, M. V. Basaveswara ^{[5
]}

Cheedarala, Ravi Kumar ^{[6
]}

Reddy, G. Rajasekhar ^{[7
]}

Naidu, Tentu Manohra ^{[8
]}

机构：

[1] Krishna Univ, Dept Chem, Machilipatnam 521001, Andhra Pradesh, India

[2] King Saud Univ, Dept Zool, Coll Sci, Riyadh 11451, Saudi Arabia

[3] King Faisal Univ, Dept Phys, Coll Sci, Al Hufuf 31982, Al Ahsa, Saudi Arabia

[4] King Saud Univ, Coll Sci, Chem Dept, Riyadh 11451, Saudi Arabia

[5] Krishna Univ, Dept Organ Chem, Machilipatnam 521001, Andhra Pradesh, India

[6] Ulsan Natl Inst Sci & Technol, UNIST Gil, Dept Mat Sci & Engn, Ulsan 44919, South Korea

[7] Anna Univ, Dept Chem Engn, AC Tech Campus, Chennai 600025, Tamil Nadu, India

[8] Andhra Univ, Dept Nucl Phys, Visakhapatnam 530003, Andhra Pradesh, India

来源：

MOLECULES | 2021年 / 26卷 / 14期

关键词：

o-phenylenediamine; nano-ZrO2; aryl aldehydes; benzimidazole; XRD; ONE-POT SYNTHESIS; OXIDE; FUNCTIONALIZATION; CONDENSATION; ALCOHOLS;

D O I：

10.3390/molecules26144219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this article, a zirconia-based nano-catalyst (Nano-ZrO2), with intermolecular C-N bond formation for the synthesis of various benzimidazole-fused heterocycles in a concise method is reported. The robustness of this reaction is demonstrated by the synthesis of a series of benzimidazole drugs in a one-pot method. All synthesized materials were characterized using (HNMR)-H-1, (CNMR)-C-13, and LC-MS spectroscopy as well as microanalysis data. Furthermore, the synthesis of nano-ZrO2 was processed using a standard hydrothermal technique in pure form. The crystal structure of nano-ZrO2 and phase purity were studied, and the crystallite size was calculated from XRD analysis using the Debye-Scherrer equation. Furthermore, the antimicrobial activity of the synthesized benzimidazole drugs was evaluated in terms of Gram-positive, Gram-negative, and antifungal activity, and the results were satisfactory.

引用

页数：14

共 37 条

[21] Corallocarpus epigaeus mediated synthesis of ZnO/CuO integrated ZrO2 nanoparticles for enhanced in-vitro antibacterial, antifungal and antidiabetic activities [J].

Shailaja, N. R. ;

Arulmozhi, M. ;

Balraj, B. ;

Siva, C. .

JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2023, 100 (05)

[22] Magnetically separable MnFe2O4 nano-material: an efficient and reusable heterogeneous catalyst for the synthesis of 2-substituted benzimidazoles and the extended synthesis of quinoxalines at room temperature under aerobic conditions [J].

Brahmachari, Goutam ;

Laskar, Sujay ;

Barik, Puspendu .

RSC ADVANCES, 2013, 3 (34) :14245-14253

[23] Visible-Light-Driven One-Pot Synthesis of Benzimidazoles, Benzothiazoles, and Quinazolinones Catalyzed by Scalable and Reusable Ba-Doped CoMoO4 Nanoparticles Under Air Atmosphere [J].

Abinaya, Ramanjulu ;

Elavarasan, Selvaraj ;

Binish, B. ;

Rahulan, K. Mani ;

Balasubramanian, Kalpattu K. ;

Manokaran, Kamaraj ;

Varathan, Elumalai ;

Baskar, Baburaj .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2023, 26 (04)

[24] Nano-Cuo-Au-catalyzed solvent-free synthesis of -aminophosphonates and evaluation of their antioxidant and -glucosidase enzyme inhibition activities [J].

Sreelakshmi, Poola ;

Santhisudha, Sarva ;

Reddy, Gajjala Raghavendra ;

Subbarao, Yakkate ;

Peddanna, Kotha ;

Apparao, Chippada ;

Reddy, Cirandur Suresh .

SYNTHETIC COMMUNICATIONS, 2018, 48 (10) :1148-1163

[25] Facile-one pot-green synthesis, antibacterial, antifungal, antioxidant and antiplatelet activities of lignin capped silver nanoparticles: A promising therapeutic agent [J].

Marulasiddeshwara, M. B. ;

Dakshayani, S. S. ;

Kumar, M. N. Sharath ;

Chethana, R. ;

Kumar, P. Raghavendra ;

Devaraja, S. .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 81 :182-190

[26] Synthesis, antibacterial, and antifungal activities of biolabile (E)-1-(4-morpholinophenyl)-3-aryl-prop-2-en-1-ones [J].

Gopalakrishnan, M. ;

Thanusu, J. ;

Kanagarajan, V. ;

Govindaraju, R. .

MEDICINAL CHEMISTRY RESEARCH, 2009, 18 (05) :341-350

[27] Nano-sized heterogeneous photocatalyst Fe3O4@V/TiO2-catalyzed synthesis and antimycobacterial evaluation of 2-substituted benzimidazoles [J].

Bao, Lijian ;

Chen, Xiaodong ;

Li, Yanli ;

Zhu, Guangyuan ;

Wang, Jingjun ;

Chen, Mingyue ;

Bian, Xingyu ;

Gu, Qiang ;

Zhang, Yumin ;

Lin, Feng .

MOLECULAR DIVERSITY, 2025,

[28] Synthesis of Polysubstituted Pyridine Derivatives via Sequential AlCl3-Catalyzed Condensation/Aza-Wittig/Isomerization Reactions and a Study of their Antifungal Activities [J].

Ren, Zhi-Lin ;

Su, Lei ;

Cai, Shuang ;

Lu, Wen-Ting ;

Qiao, Yue ;

He, Ping ;

Ding, Ming-Wu .

ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 8 (08) :1394-1397

[29] Solvent-free one-pot synthesis, characterization, antibacterial and antifungal activities of novel spiropiperidinyl-1,2,4-triazolidine-3-thiones [J].

V. Kanagarajan ;

J. Thanusu ;

M. R. Ezhilarasi ;

M. Gopalakrishnan .

Chemistry of Heterocyclic Compounds, 2011, 47 :60-66

[30] Preparation and Characterization of a Novel Magnetic Nano Catalyst for Synthesis and Antibacterial Activities of Novel Furan-2(5H)-Ones Derivatives [J].

Hao, Feng ;

Wang, Xia ;

Mohammadnia, Majid .

POLYCYCLIC AROMATIC COMPOUNDS, 2022, 42 (07) :4255-4268

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