Switching from contextual to tone fear conditioning and vice versa: The key role of the glutamatergic hippocampal-lateral septal neurotransmission

被引：22

作者：

Calandreau, Ludovic ^{[1
,2
]}

Desgranges, Bertrand ^{[2
]}

Jaffard, Robert ^{[1
]}

Desmedt, Aline ^{[1
]}

机构：

[1] Univ Bordeaux, CNRS, UMR 5228, Ctr Neurosci Integrat & Cognit, F-33405 Talence, France

[2] Univ Tours, CNRS, UMR 6175, INRA UMR 85, F-37380 Nouzilly, France

来源：

LEARNING & MEMORY | 2010年 / 17卷 / 09期

关键词：

SYNAPTIC EXCITABILITY; MICE; AMYGDALA; VASOPRESSIN; EXPLICIT; LESIONS; SLICES; BRAIN; CUES;

D O I：

10.1101/lm.1859810

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the present experiment was to directly assess the role of the glutamatergic hippocampal-lateral septal (HPC-LS) neurotransmission in tone and contextual fear conditioning. We found that pretraining infusion of glutamatergic acid into the lateral septum promotes tone conditioning and concomitantly disrupts contextual conditioning. Infusion of glutamatergic antagonist, on the contrary, promotes contextual conditioning to the detriment of tone fear conditioning. These findings highlight the direct contribution of the glutamatergic HPC-LS neurotransmission to the adaptive selection among environmental stimuli of those that best predict the occurrence of the aversive event.

引用

收藏

页码：440 / 443

页数：4

相关论文

共 25 条

[1] A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning [J].

Calandreau, L ;

Desmedt, A ;

Decorte, L ;

Jaffard, R .

LEARNING & MEMORY, 2005, 12 (04) :383-388

[2] Dissociated roles for the lateral and medial septum in elemental and contextual fear conditioning [J].

Calandreau, Ludovic ;

Jaffard, Robert ;

Desmedt, Aline .

LEARNING & MEMORY, 2007, 14 (06) :422-429

[3] Extracellular hippocampal acetylcholine level controls amygdala function and promotes adaptive conditioned emotional response [J].

Calandreau, Ludovic ;

Trifilieff, Pierre ;

Mons, Nicole ;

Costes, Laurence ;

Marien, Marc ;

Marighetto, Aline ;

Micheau, Jacques ;

Jaffard, Robert ;

Desmedt, Aline .

JOURNAL OF NEUROSCIENCE, 2006, 26 (52) :13556-13566

[4] Differential involvement of the lateral and medial divisions of the septal area on spatial learning processes as revealed by intracranial self-administration of morphine in mice [J].

Cazala, P ;

Norena, A ;

Le Merrer, J ;

Caley, D .

BEHAVIOURAL BRAIN RESEARCH, 1998, 97 (1-2) :179-188

[5]

Desmedt A, 1998, J NEUROSCI, V18, P480

[6] An 8-day extensive elemental, but not contextual, fear conditioning potentiates hippocampal-lateral septal synaptic efficacy in mice [J].

Desmedt, A ;

Garcia, R ;

Jaffard, R .

SYNAPSE, 2003, 49 (04) :270-278

[7] The effects of ibotenic hippocampal lesions on discriminative fear conditioning to context in mice: impairment or facilitation depending on the associative value of a phasic explicit cue [J].

Desmedt, A ;

Marighetto, A ;

Garcia, R ;

Jaffard, R .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (09) :1953-1963

[8] Vasopressin in the lateral septum promotes elemental conditioning to the detriment of contextual fear conditioning in mice [J].

Desmedt, A ;

Garcia, R ;

Jaffard, R .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (11) :3913-3921

[9]

FANSELOW MS, 1980, PAVLOVIAN J BIOL SCI, V15, P177

[10] The neuroanatomical and neurochemical basis of conditioned fear [J].

Fendt, M ;

Fanselow, MS .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1999, 23 (05) :743-760