cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading

被引：371

作者：

Louis, David N. ^{[1
]}

Wesseling, Pieter ^{[2
,3
]}

Aldape, Kenneth ^{[4
]}

Brat, Daniel J. ^{[5
]}

Capper, David ^{[6
,7
,8
,9
,10
]}

Cree, Ian A. ^{[11
]}

Eberhart, Charles ^{[12
]}

Figarella-Branger, Dominique ^{[13
]}

Fouladi, Maryam ^{[14
]}

Fuller, Gregory N. ^{[15
]}

Giannini, Caterina ^{[16
,17
]}

Haberler, Christine ^{[18
]}

Hawkins, Cynthia ^{[19
]}

Komori, Takashi ^{[20
]}

Kros, Johan M. ^{[21
]}

Ng, H. K. ^{[22
]}

Orr, Brent A. ^{[23
]}

Park, Sung-Hye ^{[24
]}

Paulus, Werner ^{[25
]}

Perry, Arie ^{[26
]}

Pietsch, Torsten ^{[27
]}

Reifenberger, Guido ^{[28
,29
]}

Rosenblum, Marc ^{[30
]}

Rous, Brian ^{[11
,31
]}

Sahm, Felix ^{[32
,33
,34
]}

Sarkar, Chitra ^{[35
]}

Solomon, David A. ^{[26
]}

Tabori, Uri ^{[36
]}

van den Bent, Martin J. ^{[37
]}

von Deimling, Andreas ^{[32
,33
]}

Weller, Michael ^{[38
,39
]}

White, Valerie A. ^{[11
]}

Ellison, David W. ^{[11
,23
]}

机构：

[1] Harvard Med Sch, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[2] Amsterdam Univ Med Ctr VUmc, Dept Pathol, Amsterdam, Netherlands

[3] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

[4] NCI, Lab Pathol, Bethesda, MD 20892 USA

[5] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA

[6] Humboldt Univ, Dept Neuropathol, Berlin, Germany

[7] Berlin Inst Hlth, Berlin, Germany

[8] Free Univ Berlin, Berlin, Germany

[9] Charite Univ Med Berlin, Berlin, Germany

[10] German Canc Res Ctr, German Canc Consortium, Partner Site Berlin, Heidelberg, Germany

[11] WHO, Int Agcy Res Canc, Lyon, France

[12] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD USA

[13] Aix Marseille Univ, Hop La Timone, AP HM,CNRS, Serv Anat Pathol & Neuropathol,Inst Neurophysiopa, Marseille, France

[14] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH USA

[15] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[16] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[17] Univ Bologna, Dept Biomed & Neuromotor Sci, Alma Mater Studiorum, Bologna, Italy

[18] Med Univ Vienna, Inst Neurol, Vienna, Austria

[19] Univ Toronto, Hosp Sick Children, Dept Paediat Lab Med, Toronto, ON, Canada

[20] Tokyo Metropolitan Neurol Hosp, Dept Lab Med & Pathol, Tokyo, Japan

[21] Erasmus MC, Dept Pathol, Rotterdam, Netherlands

[22] Chinese Univ Hong Kong, Dept Anat & Cellular Pathol, Hong Kong, Peoples R China

[23] St Jude Childrens Res Hosp, Dept Pathol, 332 N Lauderdale St, Memphis, TN 38105 USA

[24] Seoul Natl Univ, Dept Pathol, Coll Med, Seoul, South Korea

[25] Univ Hosp Munster, Inst Neuropathol, Munster, Germany

[26] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[27] Univ Bonn, DGNN Brain Tumor Reference Ctr, Dept Neuropathol, Bonn, Germany

[28] Heinrich Heine Univ, Dept Neuropathol, Dusseldorf, Germany

[29] German Canc Consortium, Partner Site Essen Duesseldorf, Essen, Germany

[30] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA

[31] Cambridge Univ Hosp NHS Fdn Trust, Dept Pathol, Cambridge, England

[32] Ruprecht Karls Univ Heidelberg, Inst Pathol, Dept Neuropathol, Heidelberg, Germany

[33] German Canc Consortium, Clin Cooperat Unit Neuropathol, German Canc Res Ctr, Heidelberg, Germany

[34] NCT Heidelberg, Hopp Childrens Canc Ctr, Heidelberg, Germany

[35] All India Inst Med Sci, Dept Pathol, New Delhi, India

[36] Univ Toronto, Hosp Sick Children, Dept Pediat, Toronto, ON, Canada

[37] Erasmus MC Canc Inst, Dept Neurol, Rotterdam, Netherlands

[38] Univ Hosp, Dept Neurol, Zurich, Switzerland

[39] Univ Zurich, Zurich, Switzerland

来源：

BRAIN PATHOLOGY | 2020年 / 30卷 / 04期

关键词：

brain tumors; central nervous system; classification; neoplasms; DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMOR; POSTERIOR-FOSSA EPENDYMOMA; VACUOLATING NEURONAL TUMOR; PEDIATRIC HIGH-GRADE; SEPTUM PELLUCIDUM; GENETIC ALTERATIONS; CLINICOPATHOLOGICAL FEATURES; MOLECULAR CLASSIFICATION; 1P DELETION; NEOPLASM;

D O I：

10.1111/bpa.12832

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid progress in molecular insights into these neoplasms. For Round 2 of its deliberations, cIMPACT-NOW Working Committee 3 was reconstituted and convened in Utrecht, The Netherlands, for a meeting designed to review putative new CNS tumor types in advance of any future World Health Organization meeting on CNS tumor classification. In preparatory activities for the meeting and at the actual meeting, a list of possible entities was assembled and each type and subtype debated. Working Committee 3 recommended that a substantial number of newly recognized types and subtypes should be considered for inclusion in future CNS tumor classifications. In addition, the group endorsed a number of principles-relating to classification categories, approaches to classification, nomenclature, and grading-that the group hopes will also inform the future classification of CNS neoplasms.

引用

页码：844 / 856

页数：13

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