Oxidative stress: Does it play a role in the genesis of early glycated proteins?

Glycation and oxidative stress are two important processes known to play a key role in complications of many pathophysiological processes. The two traditional factors found to modulate the early glycation of proteins are the prevailing concentration of glucose and half life of the protein. But evidences in the literature have documented an increased glycated protein levels in some non-diabetic pathological states. So it stands to reason that hyperglycemia, while clearly the culprit in diabetes, is not the complete answer to the etiology of increased early glycated products in non-diabetic conditions. A common denominator in all these above mentioned non-diabetic pathological conditions is oxidative stress. Collective evidences from the literature reveal that malondialdehyde, reduced glutathione, vitamin C, vitamin E and drugs with antioxidant properties mitigate the process of protein glycation. Taking all the above factors into account, we hypothesis that oxidative stress either via increasing reactive oxygen species or by depleting the antioxidants may modulate the genesis of early glycated proteins in vivo. (C) 2007 Elsevier Ltd. All rights reserved.