Experimental infection of early pregnant cows with bovine viral diarrhea virus: Transmission of virus to the reproductive tract and conceptus

被引：9

作者：

Tsuboi, T. ^{[1
]}

Osawa, T. ^{[2
]}

Kimura, K. ^{[3
]}

Kubo, M. ^{[4
]}

Haritani, M. ^{[3
]}

机构：

[1] Natl Inst Anim Hlth, Res Team Environm Enzoot Dis, Aomori 0392586, Japan

[2] Iwate Univ, Dept Vet Med, Morioka, Iwate 0208550, Japan

[3] Natl Inst Anim Hlth, Res Team Bacterial Parasit Dis, Tsukuba, Ibaraki 3050856, Japan

[4] Natl Inst Anim Hlth, Ctr Anim Dis Control & Prevent, Tsukuba, Ibaraki 3050856, Japan

来源：

RESEARCH IN VETERINARY SCIENCE | 2011年 / 90卷 / 01期

关键词：

Bovine viral diarrhea virus; Early pregnant cow; Embryo; Experimental infection; Plasma progesterone concentration; DAIRY HERDS; PESTIVIRUS; EMBRYOS; IMPACT; CATTLE; CALVES; VITRO;

D O I：

10.1016/j.rvsc.2010.04.024

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The objective of this study was to chronologically investigate the effect of bovine viral diarrhea virus (BVDV) infection on early pregnant cows before placenta formation. Six cows were intravenously inoculated with either BVDV (treated, n = 4) or growth medium (control, n = 2) (day 0) at day 26 of pregnancy. Two treated cows and one control cow were euthanized on day 3 post-infection and the remaining animals were euthanized on day 6. BVDV was isolated from maternal tissues such as lymphoid or reproductive tissues of treated animals on days 3 and 6 post-infection. Additionally, one treated cow autopsied on day 6 post-infection had evidence of infectious BVDV in the allantoic membranes, allantoic fluid and embryos. In three treated cows, a significant decline in progesterone concentration was also observed post-infection while in control cows they remained constant. Therefore, BVDV can infect bovine embryos before placenta formation and may affect progesterone profiles in cows during early pregnancy. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：174 / 178

页数：5