Tetraspanin functions during HIV-1 and influenza virus replication

被引:32
作者
Thali, Markus [1 ,2 ]
机构
[1] Univ Vermont, Dept Microbiol & Mol Genet, Coll Med, Burlington, VT 05405 USA
[2] Univ Vermont, CALS, Burlington, VT 05405 USA
关键词
Env; HIV-1; influenza; membrane fusion; tetraspanin; virus replication; MEMBRANE MICRODOMAINS; PLASMA-MEMBRANE; PROTEINS; FUSION; TYPE-1; ROLES;
D O I
10.1042/BST0390529
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
By virtue of their multiple interactions with partner proteins and due to their strong propensity to multimerize, tetraspanins create scaffolds in membranes, recruiting or excluding specific proteins needed for particular cellular processes. We and others have shown that (i) HIV-1 assembles at, and buds through, membrane areas that are enriched in tetraspanins CD9, CD63, CD81 and CD82, and (ii) the presence of these proteins at exit sites and in viral particles inhibits virus-induced membrane fusion. In the present paper, I review these findings and briefly discuss the results of our ongoing investigations that are aimed at elucidating when and how tetraspanins regulate this fusion process and how such control affects virus spreading. Finally, I give a preview of studies that we have initiated more recently and which aim to delineate exactly when CD81 functions during the replication of another enveloped RNA virus: influenza virus.
引用
收藏
页码:529 / 531
页数:3
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