AKT inhibitor KP372-1 induces growth arrest, apoptosis and down-regulation of phospho-ERK1/2 in primary AML cells.

被引:0
|
作者
Ricciardi, MR [1 ]
Konopleva, M [1 ]
Mills, GB [1 ]
Andreeff, M [1 ]
机构
[1] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2309
引用
收藏
页码:625A / 626A
页数:2
相关论文
共 50 条
  • [41] Curcumin inhibits cell growth and invasion and induces apoptosis through down-regulation of Skp2 in pancreatic cancer cells
    Su, Jingna
    Zhou, Xiuxia
    Wang, Lixia
    Yin, Xuyuan
    Wang, Zhiwei
    AMERICAN JOURNAL OF CANCER RESEARCH, 2016, 6 (09): : 1949 - 1962
  • [42] Transforming growth factor-beta1 induces epithelial to mesenchymal transition through down-regulation of Dickkopf-1 in human A549 lung cancer cells.
    Choi, Y.
    Kim, B.
    MOLECULAR BIOLOGY OF THE CELL, 2016, 27
  • [43] Down-regulation of the cyclin E1 oncogene expression by microRNA-16-1 induces cell cycle arrest in human cancer cells
    Wang, Fu
    Fu, Xiang-Dong
    Zhou, Yu
    Zhang, Yi
    BMB REPORTS, 2009, 42 (11) : 725 - 730
  • [44] Fibroblast Growth Factor 2 Induces E-Cadherin Down-Regulation via PI3K/Akt/mTOR and MAPK/ERK Signaling in Ovarian Cancer Cells
    Lau, Man-Tat
    So, Wai-Kin
    Leung, Peter C. K.
    PLOS ONE, 2013, 8 (03):
  • [45] Andrographolide induces apoptosis via down-regulation of glyoxalase 1 and HMG-CoA reductase in HL-60 cells
    Chen, Chun-Chia
    Wu, Mei-Li
    Doerksen, Robert J.
    Ho, Chi-Tang
    Huang, Tzou-Chi
    JOURNAL OF FUNCTIONAL FOODS, 2015, 14 : 226 - 235
  • [46] HY558, a novel cell cycle inhibitor, induces G1/G2 arrest and apoptosis in the human cancer cells.
    Lee, C
    Lim, H
    Kim, M
    Cho, Y
    AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (04) : 229 - 229
  • [47] Antiproliferative and Proapoptotic Activity of Sunitinib on Endothelial and Anaplastic Thyroid Cancer Cells via Inhibition of Akt and ERK1/2 Phosphorylation and by Down-Regulation of Cyclin-D1
    Di Desidero, Teresa
    Fioravanti, Anna
    Orlandi, Paola
    Canu, Bastianina
    Giannini, Riccardo
    Borrelli, Nicla
    Man, Shan
    Xu, Ping
    Fontanini, Gabriella
    Basolo, Fulvio
    Kerbel, Robert S.
    Francia, Giulio
    Danesi, Romano
    Bocci, Guido
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (09): : E1465 - E1473
  • [48] Effects of Lidocaine and Ropivacaine on Gastric Cancer Cells Through Down-regulation of ERK1/2 Phosphorylation In Vitro
    Yang, Wenjing
    Cai, Jun
    Zhang, Huiming
    Wang, Guyan
    Jiang, Wenguo
    ANTICANCER RESEARCH, 2018, 38 (12) : 6729 - 6735
  • [49] Thyroid hormone induces apoptosis of GH4C1 cells through a mechanism involving activation of the ERK/DUSP1 pathway and down-regulation of NF-κB activity
    Chiloeches, A.
    Sanchez-Pacheco, A.
    Gil-Araujo, B.
    Aranda, A.
    Lasa, M.
    FEBS JOURNAL, 2008, 275 : 312 - 312
  • [50] Roxithromycin treatment inhibits TGF-β1-induced activation of ERK and AKT and down-regulation of Caveolin-1 in rat airway smooth muscle cells
    Yuanrong Dai
    Fengqin Li
    Liqin Wu
    Ruili Wang
    Ping Li
    Sunshun Yan
    Hui Xu
    Mengling Xia
    Chunxue Bai
    Respiratory Research, 15