Effect of stobadine on superoxide generation and degranulation of stimulated human polymorphonuclear leukocytes in vitro

被引：0

作者：

Pecivová, J ^{[1
]}

Macicková, T ^{[1
]}

Nosál', R ^{[1
]}

Danihelová, E ^{[1
]}

机构：

[1] Slovak Acad Sci, Inst Expt Pharmacol, SK-84126 Bratislava, Slovakia

来源：

BIOLOGIA | 2000年 / 55卷

关键词：

human PMN leukocytes; stobadine; superoxide anion; enzyme release; FMLP; PMA;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We studied the effect of stobadine, a pyridoindole antioxidant agent, on superoxide anion (O-2(.-)) generation (respiratory burst) and enzyme (lysozyme and myeloperoxidase) release from FMLP (a specific receptor activator) and from PMA (activator of protein kinase C) stimulated human polymorphonuclear leukocytes (PMNL). Stabadine (1, 10 and 100 muM) decreased O-2(.-) generation ill FMLP stimulated PMNL only. It had no significant effect on enzyme release. The stobadine effect on O-2(.-) generation seems to be linked to signal transduction rather than to its free radical scavenging and antioxidant properties since there v;as no effect on O-2(.-) generation in PMA stimulated PMNL.

引用

页码：103 / 106

页数：4

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