Medication Adherence of Statin Users after Acute Ischemic Stroke

被引：25

作者：

Chung, Pil-Wook ^{[1
]}

Yoon, Byung-Woo ^{[2
]}

Lee, Yeong-Bae ^{[3
]}

Shin, Byoung-Soo ^{[4
]}

Kim, Hahn Young ^{[5
,6
]}

Park, Jae Hyeon ^{[7
]}

Kim, Byung-Kun ^{[8
]}

Yoo, Bong-Goo ^{[9
]}

Shin, Won-chul ^{[10
]}

Kim, Eung-Gyu ^{[11
]}

Do, Jin Kuk ^{[12
]}

Park, Kyung-Pil ^{[13
]}

Jung, Yohan ^{[14
]}

Seo, Woo-Keun ^{[15
,16
]}

Han, Moon-Ku ^{[17
]}

Kim, Jei ^{[18
]}

Kim, Yongduk ^{[19
]}

Bang, Oh Young ^{[20
]}

Hwang, Yang-Ha ^{[21
,22
]}

Cha, Jin-Hye ^{[23
]}

Kim, Young-Joo ^{[23
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Neurol, Seoul, South Korea

[2] Seoul Natl Univ Hosp, Dept Neurol, Seoul, South Korea

[3] Gachon Univ, Dept Neurol, Coll Med, Gil Med Ctr, Incheon, South Korea

[4] Chonbuk Natl Univ, Dept Neurol, Med Sch & Hosp, Jeonju, South Korea

[5] Konkuk Univ, Dept Neurol, Med Ctr, Seoul, South Korea

[6] Konkuk Univ, Sch Med, Seoul, South Korea

[7] Inje Univ, Sanggye Paik Hosp, Dept Neurol, Seoul, South Korea

[8] Eulji Gen Hosp, Dept Neurol, Seoul, South Korea

[9] Kosin Univ, Dept Neurol, Gospel Hospita, Busan, South Korea

[10] Kyung Hee Univ Hosp Gangdong, Dept Neurol, Seoul, South Korea

[11] Inje Univ, Dept Neurol, Busan Paik Hosp, Busan, South Korea

[12] Catholic Univ Daegu, Sch Med, Dept Neurol, Daegu, South Korea

[13] Pusan Natl Univ, Sch Med, Yangsan Hosp, Dept Neurol, Yangsan, South Korea

[14] Changwon Fatima Hosp, Dept Neurol, Changwons, South Korea

[15] Korea Univ, Dept Neurol, Guro Hosp, Seoul, South Korea

[16] Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Seoul, South Korea

[17] Seoul Natl Univ, Dept Neurol, Bundang Hosp, Seongnam, South Korea

[18] Chungnam Natl Univ Hosp, Dept Neurol, Daejeon, South Korea

[19] Konyang Univ, Div Movement Disorder, Dept Neurol, Coll Med, Daejeon, South Korea

[20] Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Seoul, South Korea

[21] Kyungpook Natl Univ, Dept Neurol, Sch Med & Hosp, Daegu, South Korea

[22] Kyungpook Natl Univ, Cerebrovasc Ctr, Sch Med & Hosp, Daegu, South Korea

[23] Pfizer Pharmaceut Korea Ltd, Outcomes Res Real World Data Team, Corp Affairs Hlth & Value Div, Seoul, South Korea

来源：

EUROPEAN NEUROLOGY | 2018年 / 80卷 / 1-2期

关键词：

Acute ischemic stroke; Statin adherence; Patient-reported outcomes; Quality of life; LONG-TERM PERSISTENCE; 1ST RECURRENT STROKE; HEART-DISEASE; THERAPY; RISK; SECONDARY; NONADHERENCE; ATORVASTATIN; VALIDITY; COHORT;

D O I：

10.1159/000493530

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although statins are established therapy for the secondary prevention of ischemic stroke, factors associated with adherence to statin treatment following ischemic stroke are not well known. To address this, we assessed the 6-month statin adherence using 8-item Morisky Medication Adherence Scale-8 in patients with acute ischemic stroke. Of 991 patients, 65.6% were adherent to statin at 6-month after discharge. Multiple logistic regression analysis showed that patients' awareness of hyperlipidemia (OR 1.62; 95% CI 1.07-2.43), large artery stroke subtype (versus non-large artery stroke, OR 1.79; 95% CI 1.19-2.68), and alcohol drinking habits (OR 1.64; 95% CI 1.06-2.53) were positively associated, while high statin dose (versus low dose, OR 0.6; 95% CI 0.40-0.90) and higher daily number of medication pills (OR 0.93; 95% CI 0.88-0.97) were found to have a negative association with self-reported good adherence to statin medication after acute ischemic stroke. However, stroke severity and diagnosis of hyperlipidemia were not associated with adherence. These results suggest that educational and motivational interventions may enhance statin adherence because modifiable factors were associated with statin adherence.

引用

页码：106 / 114

页数：9

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