The peritrophic matrix limits the rate of digestion in adult Anopheles stephensi and Aedes aegypti mosquitoes

被引：47

作者：

Villalon, JM ^{[1
]}

Ghosh, A ^{[1
]}

Jacobs-Lorena, M ^{[1
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Genet, Cleveland, OH 44106 USA

来源：

JOURNAL OF INSECT PHYSIOLOGY | 2003年 / 49卷 / 10期

基金：

美国国家卫生研究院;

关键词：

mosquito; peritrophic matrix; digestion;

D O I：

10.1016/S0022-1910(03)00135-5

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

The peritrophic matrix (PM) is a chitin-containing acellular sheath that surrounds the blood meal and separates the food bolus from the midgut epithelium. Intense molecular traffic through the PM occurs during digestion. Digestive enzymes secreted by the midgut epithelium must traverse the PM to reach their substrates in the food bolus, and digestion products must cross the PM in the opposite direction to be absorbed by the epithelial cells. Here we report that the PM limits the rate of digestion. PM disruption by two independent means (chitinase and anti-PM antibodies) consistently increases the rate of blood digestion. The significance of these results in relation to PM function is discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：891 / 895

页数：5