EPH receptor signalling casts a wide net on cell behaviour

被引：864

作者：

Pasquale, EB

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1662

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eph receptor tyrosine kinases mould the behaviour of many cell types by binding membrane-anchored ligands, ephrins, at sites of cell-cell contact. Eph signals affect both of the contacting cells and can produce diverse biological responses. New models explain how quantitative variations in the densities and signalling abilities of Eph receptors and ephrins could account for the different effects that are elicited on axon guidance, cell adhesion and cell migration during development, homeostasis and disease.

引用

收藏

页码：462 / 475

页数：14

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