An expedient synthesis of 3-acyltetramic acids of the melophlin family from α-aminoesters and immobilized Ph3PCCO

被引：40

作者：

Schobert, R ^{[1
]}

Jagusch, C ^{[1
]}

机构：

[1] Univ Bayreuth, Organ Chem Lab, D-95440 Bayreuth, Germany

来源：

TETRAHEDRON | 2005年 / 61卷 / 09期

关键词：

tetramic acids; phosphorus ylides; solid phase organic synthesis; immobilized reagents; melophlins; microwave;

D O I：

10.1016/j.tet.2005.01.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The naturally occurring 3-acyltetramic acids (3-acylpyrrolidine-2,4-diones) melophlin A, B, C and G were prepared in few steps from alpha-aminoesters or their hydrochlorides by cyclization with Ph3PCCO under mild conditions. The employment of immobilized, polystyrene-bound ylide greatly simplifies the removal of by-product Ph3PO and of other impurities. Various 3-acylation methods were assessed. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2301 / 2307

页数：7

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