Evolutionary Game Theoretical Approach for Understanding CCR5 to CXCR4 Coreceptor Switch

被引：0

作者：

Wu, Jing ^{[1
]}

Bewick, Sharon ^{[1
]}

Yang, Ruoting ^{[1
]}

Lenaghan, Scott C. ^{[1
]}

Zhang, Mingjun ^{[1
]}

机构：

[1] Univ Tennessee, Dept Mech Aerosp & Biomed Engn, Knoxville, TN 37996 USA

来源：

2010 AMERICAN CONTROL CONFERENCE | 2010年

关键词：

HIV-1; PROGRESSION; PHENOTYPE; HOST; DNA;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

This paper shows how a game theoretical analysis can provide a model to determine the factors affecting the switch from CXCR4 coreceptor (X4) to CCR5 coreceptor (R5) in HIV-1 infected individuals. Simulations of the model predict that a persistent immune response suppresses the X4-tropic virus to a low level at first, but later increases in the immune response will trigger the switch from X4 to R5 coreceptor. In addition, we find various factors that impact the switching time.

引用

页码：6722 / 6727

页数：6

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