Gemcitabine and carboplatin in combination for the treatment of advanced, metastatic, non-small cell lung cancer

被引：9
|
作者：
Nagel, Sylke [3 ]
Califano, Raffaele [2 ]
Thatcher, Nicholas [1 ]
Blackhall, Fiona [1 ]
机构：
[1] Christie Hosp, Dept Med Oncol, Manchester M20 4BX, Lancs, England
[2] Osped Santa Maria Misericordia, SC Oncol Med, I-06120 Perugia, Italy
[3] Martha Maria Hosp, D-06120 Halle, Germany
来源：
EXPERT OPINION ON PHARMACOTHERAPY | 2007年 / 8卷 / 18期
关键词：
carboplatin; chemotherapy; gemcitabine; non-small-cell lung cancer;
D O I：
10.1517/14656566.8.18.3265
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The universally accepted first-line treatment for advanced (stage IIIB effusion/IV) non-small-cell lung cancer in patients with a good performance status is a platinum drug in combination with one of gemcitabine, paclitaxel, vinorelbine or docetaxel. Although cisplatin is generally the favoured platinum agent, gemcitabine partnered with carboplatin is convenient to administer and has a favourable toxicity profile. Here, the pharmacology, preclinical and clinical data to support the use of this regimen for the treatment of advanced non-small-cell lung cancer is evaluated.
引用
收藏
页码：3265 / 3275
页数：11
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