CYP2A6 gene polymorphism and personality traits for NEO-FFI on the smoking behavior of youths

被引：7

作者：

Waga, Chikako

Iwahashi, Kazuhiko

机构：

[1] Azabu Univ, Hlth Adm Ctr, Dept Neurophysiol, Sagamihara, Kanagawa, Japan

[2] Grad Sch Environm Hlth, Dept Neurol, Kanagawa, Japan

来源：

DRUG AND CHEMICAL TOXICOLOGY | 2007年 / 30卷 / 04期

关键词：

CYP2A6; nicotine dependence; openness; NICOTINE METABOLISM; VARIANT;

D O I：

10.1080/01480540701522338

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We performed a survey on the relationship between nicotine dependence and psychological (the personality traits using neuroticism extroversion openess-five factor inventory (NEO-FFI)/nicotine metabolism (the CYP2A6 gene polymorphism) factors among Japanese young students to elucidate the mechanism of the development of nicotine dependence. As a result, the frequency of the CYP2A6*4C gene (enzyme activity deficit) was significantly (p < 0.05) higher among nonsmokers than smokers, and the Openness score by NEO-FFI was higher among smokers than nonsmokers. However, there were no significant differences in the Neuroticism, Extraversion, Agreeableness, and Conscientiousness scores by NEO-FFI between smokers and nonsmokers. We conclude that the CYP2A6*4C gene and the Openness personality trait may affect the development of the smoking behavior of youth.

引用

页码：343 / 349

页数：7

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