Nickel complexes from α-amino amides as efficient catalysts for the enantioselective Et2Zn addition to benzaldehyde

被引：43

作者：

Burguete, MI ^{[1
]}

Collado, M ^{[1
]}

Escorihuela, J ^{[1
]}

Galindo, F ^{[1
]}

García-Verdugo, E ^{[1
]}

Luis, SV ^{[1
]}

Vicent, MJ ^{[1
]}

机构：

[1] Univ Jaume 1, Dept Inorgan & Organ Chem, ESTCE, E-12080 Castellon de La Plana, Spain

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(03)01705-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ni2+ complexes derived from simple alpha-amino amides catalyze very efficiently the addition of Et2Zn to benzaldehyde, giving (S)-1-phenylethanol as the major isomer in most cases (94% yield, 97% ee for R=Bn). The nature of the substituent on the amide nitrogen atom seems to play a key role in determining the asymmetric induction observed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6891 / 6894

页数：4

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