Changes in some blood biochemical and haematological parameters in goats after aminoglycoside and aminocyclitol treatment at therapeutic doses

The aim of the present study was to determine the changes in some blood biochemical and haematological parameters in healthy female goats after a 5-day parenteral treatment with gentamicin (4 mg/kg), tobramycin (5 mg/kg), amikacin (10 mg/kg), kanamycin (10 mg/kg), apramycin (20 mg/kg), and spectinomycin (20 mg/kg). The results indicated that aminoglycosides caused more severe alterations than aminocyclitols, especially on those parameters related to renal function. There was a tendency toward a rise in plasma creatinine and urea levels after aminoglycoside treatment, as well as a rise in urea levels after aminocyclitol administration. These antibiotics caused decreases in plasma or serum glucose, sodium and chloride levels, erythrocytes and leukocytes counts, haematocrit percentage and haemoglobin concentration. For plasma or serum total protein, total lipids, lactate dehydrogenase, alkaline phosphatase, calcium, and magnesium concentrations and differential white blood cell counts, various changes occurred. As a whole, these antibiotics have the potential to alter biochemical and haematological values in female goats after their use at therapeutic doses.