The subthalamic nucleus exerts opposite control on cocaine and 'natural' rewards

被引：169

作者：

Baunez, C ^{[1
]}

Dias, C

Cador, M

Amalric, M

机构：

[1] Univ Aix Marseille 1, CNRS, UMR 6155, Lab Neurobiol Cognit, F-13402 Marseille, France

[2] Univ Bordeaux 2, CNRS, UMR 5541, Lab Neuropsychobiol Desadaptat, F-33076 Bordeaux, France

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 04期

关键词：

D O I：

10.1038/nn1429

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A challenge in treating drug addicts is preventing their pathological motivation for the drug without impairing their general affective state toward natural reinforcers. Here we have shown that discrete lesions of the subthalamic nucleus greatly decreased the motivation of rats for cocaine while increasing it for food reward. The subthalamic nucleus, a key structure controlling basal ganglia outputs, is therefore able to oppositely modulate the effect of 'natural' rewards and drugs of abuse on behavior. Modulating the activity of the subthalamic nucleus might prove to be a new target for the treatment of cocaine addiction.

引用

页码：484 / 489

页数：6

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