Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor

被引：15
作者：
Chen, ZM
Miller, WS
Shan, S
Valenzano, KJ
机构：
[1] Purdue Pharma LP, Computat Combinatorial & Med Chem, Cranbury, NJ 08512 USA
[2] Purdue Pharma LP, Mol Pharmacol, Cranbury, NJ 08512 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 19期
关键词：
D O I：
10.1016/S0960-894X(03)00665-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Based on literature structures, we proposed a pharmacophore for NOP receptor ligands and used it as a guide for the design of a focused piperidine library and an optimization library. Potent NOP receptor agonists and antagonists were obtained from these libraries as well as a few potent, mu selective agonists. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3247 / 3252
页数：6
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