Metastatic niche functions and therapeutic opportunities

被引：132
作者：
Celia-Terrassa, Toni [1 ,2 ]
Kang, Yibin [2 ]
机构：
[1] IMIM Hosp Mar Med Res Inst, Canc Res Program, Barcelona, Spain
[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
来源：
NATURE CELL BIOLOGY | 2018年 / 20卷 / 08期
基金：
美国国家卫生研究院;
关键词：
BREAST-CANCER CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; STEM-CELLS; BRAIN METASTASIS; BONE METASTASIS; TUMOR-CELLS; SUPPRESSOR-CELLS; PREMETASTATIC NICHE; PANCREATIC-CANCER; INITIATING CELLS;
D O I：
10.1038/s41556-018-0145-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche.
引用
收藏
页码：868 / 877
页数：10
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