Cadmium-induced malignant transformation of human prostate epithelial cells

被引：0
|
作者：
Achanzar, WE
Diwan, BA
Liu, J
Quader, ST
Webber, MM
Waalkes, MP
机构：
[1] NIEHS, Inorgan Carcinogenesis Sect, Comparat Carcinogenesis Lab, NCI, Res Triangle Pk, NC 27709 USA
[2] NCI, Frederick Canc Res & Dev Ctr, Sci Applicat Int Corp Frederick, Intramural Res Support Program, Frederick, MD 21702 USA
[3] Michigan State Univ, Dept Med, E Lansing, MI 48824 USA
[4] Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA
来源：
CANCER RESEARCH | 2001年 / 61卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer has become epidemic, and environmental factors such as cadmium may be partly responsible. This study reports malignant transformation of the nontumorigenic human prostatic epithelial cell line RWPE-1 by in vitro cadmium exposure. The cadmium-transformed cells exhibited a loss of contact inhibition in vitro and rapidly formed highly invasive and occasionally metastatic adenocarcinomas upon inoculation into mice. The transformed cells also showed increased secretion of MMP-2 and MMP-9, a phenomenon observed in human prostate tumors and linked to aggressive behavior. Cadmium-induced malignant transformation of human prostate epithelial cells strongly fortifies the evidence for a potential role of cadmium in prostate cancer.
引用
收藏
页码：455 / 458
页数：4
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