Plant-made pharmaceuticals for the prevention and treatment of autoimmune diseases: where are we?

被引：14
作者：
Avesani, Linda [1 ]
Bortesi, Luisa [1 ]
Santi, Luca [2 ]
Falorni, Alberto [3 ]
Pezzotti, Mario [1 ]
机构：
[1] Univ Verona, Dipartimento Biotecnol, I-37134 Verona, Italy
[2] Univ Roma Tor Vergata, Dipartimento Biol, I-00133 Rome, Italy
[3] Univ Perugia, Dipartimento Med Interna, I-06126 Perugia, Italy
来源：
EXPERT REVIEW OF VACCINES | 2010年 / 9卷 / 08期
关键词：
autoantigen; autoimmune disease; oral tolerance; plant-made pharmaceutical; recombinant protein; transgenic plant; HUMAN TISSUE TRANSGLUTAMINASE; TOXIN-B-SUBUNIT; COLLAGEN-INDUCED ARTHRITIS; RECOMBINANT HUMAN INTERLEUKIN-4; INSULIN FUSION PROTEIN; II-COLLAGEN; CHOLERA-TOXIN; TRANSGENIC TOBACCO; ESCHERICHIA-COLI; MOUSE MODEL;
D O I：
10.1586/ERV.10.82
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Molecular farming in plants or plant cell cultures represents a viable alternative technology that holds great promise for the low-cost and large-scale production of recombinant proteins. The particular case of plant-based vaccines for the prevention of autoimmune diseases is addressed here, presenting a comprehensive overview of the different molecules and expression technologies that have been investigated so far in both academia and industry. The potential of plants not only as bioreactors but also as delivery systems for pharmaceuticals is discussed, and the advantages of oral delivery of autoantigens for the induction of immune tolerance are highlighted.
引用
收藏
页码：957 / 969
页数：13
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