Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice

被引：17

作者：

Westover, Jonna B. ^{[1
]}

Hickerson, Brady T. ^{[1
]}

Van Wettere, Arnaud J. ^{[1
,2
]}

Hurst, Brett L. ^{[1
]}

Kurz, Jacqueline P. ^{[1
,2
]}

Dagley, Ashley ^{[1
]}

Wuelfroth, Petra ^{[3
]}

Komeno, Takashi ^{[4
]}

Furuta, Yousuke ^{[4
]}

Steiner, Thomas ^{[3
]}

Gowen, Brian B. ^{[1
]}

机构：

[1] Utah State Univ, Dept Anim Dairy & Vet Sci, Logan, UT 84322 USA

[2] Utah State Univ, Utah Vet Diagnost Lab, Logan, UT 84341 USA

[3] MChE Trading Handels GmbH, A-1060 Vienna, Austria

[4] FUJIFILM Toyama Chem Co Ltd, Toyama 9308508, Japan

来源：

PATHOGENS | 2019年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

severe fever with thrombocytopenia syndrome; Huaiyangshan banyangvirus; viral hemorrhagic fever; vascular leak; cytokine storm; SOUTH-KOREA; BUNYAVIRUS; PATHOGENESIS;

D O I：

10.3390/pathogens8040158

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR(-/-) mice challenged with the HB29 strain of SFTS virus (SFTSV) and demonstrate hallmark features of VHF such as vascular leak and high concentrations of proinflammatory cytokines in blood and tissues. Treatment with FX06, a natural plasmin digest product of fibrin in clinical development as a treatment for vascular leak, reduced vascular permeability associated with SFTSV infection but did not significantly improve survival outcome. Further studies are needed to assess the role of vascular compromise in the SFTS disease process modeled in IFNAR(-/-) mice.

引用

页数：17

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