Proteomics and circadian rhythms: It's all about signaling!

被引：24

作者：

Mauvoisin, Daniel ^{[1
]}

Dayon, Loic ^{[2
]}

Gachon, Frederic ^{[1
]}

Kussmann, Martin ^{[2
,3
,4
]}

机构：

[1] NIHS, Circadian Rhythm Grp, CH-1015 Lausanne, Switzerland

[2] NIHS, Mol Biomarkers Core, CH-1015 Lausanne, Switzerland

[3] Ecole Polytech Fed Lausanne, Fac Life Sci, CH-1015 Lausanne, Switzerland

[4] Aarhus Univ, Fac Sci, Interdisciplinary NanoSci Ctr iNANO, Aarhus, Denmark

来源：

PROTEOMICS | 2015年 / 15卷 / 2-3期

基金：

欧洲研究理事会;

关键词：

Animal proteomics; Circadian rhythms; Metabolism; Phosphorylation; Posttranslational modifications; SILAC; CONTROLS LIPID-METABOLISM; REV-ERBA-ALPHA; GENE-EXPRESSION; SHIFT WORK; CLOCK; MOUSE; TRANSCRIPTION; ENTRAINMENT; ACTIVATION; COORDINATION;

D O I：

10.1002/pmic.201400187

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteomic technologies using MS offer new perspectives in circadian biology, in particular the possibility to study PTMs. To date, only very few studies have been carried out to decipher the rhythmicity of protein expression in mammals with large-scale proteomics. Although signaling has been shown to be of high relevance, comprehensive characterization studies of PTMs are even more rare. This review aims at describing the actual landscape of circadian proteomics and the opportunities and challenges appearing on the horizon. Emphasis was given to signaling processes for their role in metabolic health as regulated by circadian clocks and environmental factors. Those signaling processes are expected to be better and more deeply characterized in the coming years with proteomics.

引用

页码：310 / 317

页数：8

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