In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system

被引：86

作者：

Chong, SH

Dando, SA

Soucek, KM

Morrison, RA

机构：

[1] Dept. of Metab. and Pharmacokinetics, Bristol-Myers Squibb P., Princeton, NJ 08543-4000

来源：

PHARMACEUTICAL RESEARCH | 1996年 / 13卷 / 01期

关键词：

D O I：

10.1023/A:1016045820933

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：120 / 123

页数：4

共 17 条

[1] LISINOPRIL - A NEW ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR [J].

ARMAYOR, GM ;

LOPEZ, LM .

DRUG INTELLIGENCE & CLINICAL PHARMACY, 1988, 22 (05) :365-372

[2] CORRELATION BETWEEN ORAL-DRUG ABSORPTION IN HUMANS AND APPARENT DRUG PERMEABILITY COEFFICIENTS IN HUMAN INTESTINAL EPITHELIAL (CACO-2) CELLS [J].

ARTURSSON, P ;

KARLSSON, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (03) :880-885

[3] ASSOCIATION OF INTESTINAL PEPTIDE-TRANSPORT WITH A PROTEIN RELATED TO THE CADHERIN SUPERFAMILY [J].

DANTZIG, AH ;

HOSKINS, J ;

TABAS, LB ;

BRIGHT, S ;

SHEPARD, RL ;

JENKINS, IL ;

DUCKWORTH, DC ;

SPORTSMAN, JR ;

MACKENSEN, D ;

ROSTECK, PR ;

SKATRUD, PL .

SCIENCE, 1994, 264 (5157) :430-433

[4] UPTAKE OF THE CEPHALOSPORIN, CEPHALEXIN, BY A DIPEPTIDE TRANSPORT CARRIER IN THE HUMAN INTESTINAL-CELL LINE, CACO-2 [J].

DANTZIG, AH ;

BERGIN, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1027 (03) :211-217

[5]

DREYFUSS J, 1977, J CLIN PHARM MAY, P300

[6]

Everett Donald W., 1992, Pharmaceutical Research (New York), V9, pS316

[7]

FOLEY J, 1988, PHARMACOLOGISTS, V30, P109

[8] INTESTINAL-ABSORPTION MECHANISM OF DIPEPTIDE ANGIOTENSIN CONVERTING ENZYME-INHIBITORS OF THE LYSYL-PROLINE TYPE - LISINOPRIL AND SQ-29,852 [J].

FRIEDMAN, DI ;

AMIDON, GL .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1989, 78 (12) :995-998

[9]

HILDAGO IJ, 1989, GASTROENTEROLOGY, V96, P736

[10]

INUI K, 1992, J PHARMACOL EXP THER, V261, P195

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