Cerebral amyloid angiopathy

被引：0

作者：

Block, F. ^{[1
]}

机构：

[1] HELIOS Kliniken Schwerin, Neurol Klin, D-19049 Schwerin, Germany

来源：

NERVENARZT | 2011年 / 82卷 / 02期

关键词：

Cerebral amyloid angiopathy; Risk factors; Apolipoprotein E; Intracerebral hemorrhage; Cerebral imaging; INTRACEREBRAL HEMORRHAGE; MICROBLEEDS; RISK;

D O I：

10.1007/s00115-010-3035-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral amyloid angiopathy (CAA) is defined by the accumulation of beta-amyloid in the walls of cortical arteries. The risk factors of CAA include advanced age and the presence of certain alleles of apolipoprotein E. CAA mostly remains asymptomatic, but the classical manifestation is intracerebral hemorrhage. A definite diagnosis can only be made on the basis of histopathological examination. Detection of lobar hemorrhages and lobar microhemorrhages in imaging investigations support the diagnosis of CAA as long as other causes can be excluded.

引用

页码：202 / 206

页数：5

共 19 条

[1] Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience .15. [J].

Ellis, RJ ;

Olichney, JM ;

Thal, LJ ;

Mirra, SS ;

Morris, JC ;

Beekly, D ;

Heyman, A .

NEUROLOGY, 1996, 46 (06) :1592-1596

[2] Bleeding Risk Analysis in Stroke Imaging before ThromboLysis (BRASIL) -: Pooled analysis of t2*-weighted magnetic resonance imaging data from 570 patients [J].

Fiehler, Jens ;

Albers, Gregory W. ;

Boulanger, Jean-Martin ;

Derex, Laurent ;

Gass, Achim ;

Hjort, Niels ;

Kim, Jong S. ;

Liebeskind, David S. ;

Neumann-Haefelin, Tobias ;

Pedraza, Salvador ;

Rother, Joachim ;

Rothwell, Peter ;

Rovira, Alex ;

Schellinger, Peter D. ;

Trenkler, Johannes .

STROKE, 2007, 38 (10) :2738-2744

[3] Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage [J].

Greenberg, SM ;

Eng, JA ;

Ning, MM ;

Smith, EE ;

Rosand, J .

STROKE, 2004, 35 (06) :1415-1420

[4] Cerebral microbleeds: a guide to detection and interpretation [J].

Greenberg, Steven M. ;

Vernooij, Meike W. ;

Cordonnier, Charlotte ;

Viswanathan, Anand ;

Salman, Rustorn Al-Shahi ;

Warach, Steven ;

Launer, Lenore J. ;

Van Buchem, Mark A. ;

Breteler, Monique M. B. .

LANCET NEUROLOGY, 2009, 8 (02) :165-174

[5]

HIROHATA M, 2010, EUR J NEURO IN PRESS

[6] Postoperative outcome of 37 patients with lobar intracerebral hemorrhage related to cerebral amyloid angiopathy [J].

Izumihara, A ;

Ishihara, T ;

Iwamoto, N ;

Yamashita, K ;

Ito, H .

STROKE, 1999, 30 (01) :29-33

[7] Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria [J].

Knudsen, KA ;

Rosand, J ;

Karluk, D ;

Greenberg, SM .

NEUROLOGY, 2001, 56 (04) :537-539

[8] Change in incidence and aetiology of intracerebral haemorrhage in Oxfordshire, UK, between 1981 and 2006: a population-based study [J].

Lovelock, C. E. ;

Molyneux, A. J. ;

Rothwell, P. M. .

LANCET NEUROLOGY, 2007, 6 (06) :487-493

[9] Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage [J].

McCarron, MO ;

Nicoll, JAR .

LANCET NEUROLOGY, 2004, 3 (08) :484-492

[10] High frequency of apolipoprotein E ε2 allele is specific for patients with cerebral amyloid angiopathy-related haemorrhage [J].

McCarron, MO ;

Nicoll, JAR .

NEUROSCIENCE LETTERS, 1998, 247 (01) :45-48

← 1 2 →