Ruthenium-Catalyzed meta-Carboxylation

被引：42

作者：

Barlow, Helen L. ^{[1
]}

Teskey, Christopher J. ^{[1
]}

Greaney, Michael F. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

C-H BOND; ORTHO-METALATION STRATEGY; REMOVABLE AUXILIARIES; ARENES; LIGAND; FUNCTIONALIZATION; BROMINATION; ALKYLATION; ACTIVATION; DERIVATIVES;

D O I：

10.1021/acs.orglett.7b03387

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The meta-carboxylation of arenes containing pyridine and other azine-directing groups is reported. Using carbon tetrabromide as the C1. source, ruthenium(III) trichloride catalysis enables functionalization of the arene meta-C-H position, affording carboxy methyl ester products after in situ reaction with methanol.

引用

页码：6662 / 6665

页数：4

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