Cognitive Functioning in Recent Onset Psychosis

被引：13

作者：

Dickerson, Faith ^{[1
]}

Stallings, Cassie ^{[1
]}

Vaughan, Crystal ^{[1
]}

Origoni, Andrea ^{[1
]}

Khushalani, Sunil ^{[1
]}

Dickinson, Dwight ^{[2
]}

Medoff, Deborah ^{[3
]}

机构：

[1] Sheppard Pratt, Baltimore, MD 21204 USA

[2] NIMH, Genes Cognit & Psychosis Program, Bethesda, MD 20892 USA

[3] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

来源：

JOURNAL OF NERVOUS AND MENTAL DISEASE | 2011年 / 199卷 / 06期

关键词：

Cognitive functioning; recent onset psychosis; schizophrenia; bipolar disorder; BIPOLAR DISORDER; NEUROPSYCHOLOGICAL DEFICITS; REPEATABLE BATTERY; SCHIZOPHRENIA; DYSFUNCTION;

D O I：

10.1097/NMD.0b013e31821cd0ff

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The purpose of the study was to compare the cognitive functioning of persons with a recent onset of psychosis with schizophrenia-spectrum disorders and bipolar disorder and nonpsychiatric controls. A total of 56 persons with a schizophrenia-spectrum disorder and 60 with bipolar disorder, all with a recent onset psychosis, and 312 nonpsychiatric controls were evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Wisconsin Card Sorting Test (WCST). Comparison of the three groups through analysis of covariance indicated a significant difference among the groups for all of the cognitive variables. Pairwise contrasts of the two recent onset groups showed a significant difference favoring the bipolar disorder group on RBANS Language (p = 0.020) and Total (p = 0.050) and a marginally significant difference on RBANS Immediate Memory (p = 0.053) but not on the other RBANS variables or on the WCST. Cognitive performance is broadly impaired in recent onset psychosis, with a cognitive advantage to bipolar disorder patients compared with schizophrenia-spectrum patients.

引用

页码：367 / 371

页数：5

共 24 条

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