Deletion of the major proteolytic site of the Helicobacter pylori cytotoxin does not influence toxin activity but favors assembly of the toxin into hexameric structures

被引：18

作者：

Burroni, D

Lupetti, P

Pagliaccia, C

Reyrat, JM

Dallai, R

Rappuoli, R

Telford, JL

机构：

[1] Chiron Spa, IRIS, I-53100 Siena, Italy

[2] Univ Siena, Dipartimento Biol Evolut, I-53100 Siena, Italy

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 11期

关键词：

D O I：

10.1128/IAI.66.11.5547-5550.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Helicobacter pylori cytotoxin is proteolytically cleaved at a flexible hydrophilic loop into two subunits. Deletion of the loop sequences had no effect on biological activity of the toxin in the HeLa cell vacuolation assay but favored the organization of the protein into hexameric rather than heptameric structures.

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收藏

页码：5547 / 5550

页数：4

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