Antibiotics, birth mode, and diet shape microbiome maturation during early life

被引：1003

作者：

Bokulich, Nicholas A. ^{[1
]}

Chung, Jennifer ^{[1
]}

Battaglia, Thomas ^{[1
]}

Henderson, Nora ^{[1
]}

Jay, Melanie ^{[1
,2
]}

Li, Huilin ^{[3
,4
]}

Lieber, Arnon D. ^{[1
]}

Wu, Fen ^{[1
,2
]}

Perez-Perez, Guillermo I. ^{[1
,5
]}

Chen, Yu ^{[1
,2
]}

Schweizer, William ^{[6
]}

Zheng, Xuhui ^{[5
]}

Contreras, Monica ^{[1
]}

Dominguez-Bello, Maria Gloria ^{[1
]}

Blaser, Martin J. ^{[1
,5
,7
]}

机构：

[1] NYU, Dept Med, Langone Med Ctr, 550 1St Ave, New York, NY 10016 USA

[2] NYU, Dept Populat Hlth, Langone Med Ctr, 550 1St Ave, New York, NY 10016 USA

[3] NYU, Dept Populat Hlth, Div Biostat, Langone Med Ctr, 550 1St Ave, New York, NY 10016 USA

[4] NYU, Dept Environm Med, Langone Med Ctr, 550 1St Ave, New York, NY 10016 USA

[5] NYU, Dept Microbiol, Langone Med Ctr, New York, NY 10016 USA

[6] NYU, Dept Obstet & Gynecol, Langone Med Ctr, New York, NY 10016 USA

[7] New York Harbor Dept Vet Affairs Med Ctr, New York, NY 10010 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2016年 / 8卷 / 343期

关键词：

INFANT GUT MICROBIOME; CESAREAN-SECTION; HUMAN-MILK; RISK; DIVERSITY; BACTERIAL; DELIVERY; IMPACT; METAANALYSIS; RESILIENCE;

D O I：

10.1126/scitranslmed.aad7121

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disruptmicrobiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered a-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.

引用

页数：13

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