Bacterial Coinfections in Coronavirus Disease 2019

被引：152

作者：

Westblade, Lars F. ^{[1
,2
]}

Simon, Matthew S. ^{[2
]}

Satlin, Michael J. ^{[1
,2
]}

机构：

[1] Weill Cornell Med, Dept Pathol & Lab Med, New York, NY 10065 USA

[2] Weill Cornell Med, Dept Med, Div Infect Dis, New York, NY 10065 USA

来源：

TRENDS IN MICROBIOLOGY | 2021年 / 29卷 / 10期

关键词：

COMMUNITY-ACQUIRED PNEUMONIA; CRITICALLY-ILL PATIENTS; PANDEMIC INFLUENZA; RISK-FACTORS; COVID-19; INFECTION; CARE; COHORT;

D O I：

10.1016/j.tim.2021.03.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial coinfections increase the severity of respiratory viral infections and were frequent causes of mortality in influenza pandemics but have not been well characterized in patients with coronavirus disease 2019 (COVID-19). The aim of this review was to identify the frequency and microbial etiologies of bacterial coinfections that are present upon admission to the hospital and that occur during hospitalization for COVID-19. We found that bacterial coinfections were present in <4% of patients upon admission and the yield of routine diagnostic tests for pneumonia was low. When bacterial coinfections did occur, Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae were the most common pathogens and atypical bacteria were rare. Although uncommon upon admission, bacterial infections frequently occurred in patients with prolonged hospitalization, and Pseudomonas aeruginosa, Klebsiella spp., and S. aureus were common pathogens. Antibacterial therapy and diagnostic testing for bacterial infections are unnecessary upon admission in most patients hospitalized with COVID-19, but clinicians should be vigilant for nosocomial bacterial infections.

引用

页码：930 / 941

页数：12

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