Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases

被引：561

作者：

Rovin, Brad H. ^{[1
]}

Adler, Sharon G. ^{[2
]}

Barratt, Jonathan ^{[3
]}

Bridoux, Frank ^{[4
]}

Burdge, Kelly A. ^{[5
]}

Chan, Tak Mao ^{[6
]}

Cook, H. Terence ^{[7
]}

Fervenza, Fernando C. ^{[8
]}

Gibson, Keisha L. ^{[9
]}

Glassock, Richard J. ^{[10
]}

Jayne, David R. W. ^{[11
]}

Jha, Vivekanand ^{[12
,13
,14
]}

Liew, Adrian ^{[15
]}

Liu, Zhi-Hong ^{[16
]}

Mejia-Vilet, Juan M. ^{[17
]}

Nester, Carla M. ^{[18
]}

Radhakrishnan, Jai ^{[19
]}

Rave, Elizabeth M. ^{[20
]}

Reich, Heather N. ^{[21
]}

Ronco, Pierre ^{[22
,23
,24
]}

Sanders, Jan-Stephan F. ^{[25
]}

Sethi, Sanjeev ^{[26
]}

Suzuki, Yusuke ^{[27
]}

Tang, Sydney C. W. ^{[6
]}

Tesar, Vladimir ^{[28
,29
]}

Vivarelli, Marina ^{[30
]}

Wetzels, Jack F. M. ^{[31
]}

Lytvyn, Lyubov ^{[32
,33
]}

Craig, Jonathan C. ^{[34
,35
]}

Tunnicliffe, David J. ^{[35
,36
]}

Howell, Martin ^{[35
,36
]}

Tonelli, Marcello A. ^{[37
]}

Cheung, Michael ^{[38
]}

Earley, Amy ^{[38
]}

Floege, Jurgen ^{[39
]}

机构：

[1] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH 43210 USA

[2] Los Angeles Biomed Res Inst, Div Nephrol & Hypertens, Los Angeles, CA USA

[3] Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

[4] Univ Hosp Poitiers, Ctr Hosp Univ, Dept Nephrol & Renal Transplantat, CIC,INSERM 1402, Poitiers, France

[5] Mass Gen Brigham Salem Hosp, Div Nephrol, Salem, MA USA

[6] Univ Hong Kong, Div Nephrol, Dept Med, Hong Kong, Peoples R China

[7] Imperial Coll London, Renal & Transplant Ctr, London, England

[8] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN USA

[9] Univ N Carolina, Kidney Ctr Chapel Hill, Chapel Hill, NC 27515 USA

[10] Univ Calif Los Angeles, Dept Med, Geffen Sch Med, Los Angeles, CA 90024 USA

[11] Univ Cambridge, Sch Clin Med, Div Expt Med & Immunotherapeut, Cambridge, England

[12] George Inst Global Hlth, New Delhi, India

[13] Imperial Coll London, Sch Publ Hlth, London, England

[14] Manipal Acad Higher Educ, Prasanna Sch Publ Hlth, Manipal, India

[15] Mt Elizabeth Novena Hosp, Kidney & Transplant Practice, Singapore, Singapore

[16] Nanjing Univ, Sch Med, Nanjing, Peoples R China

[17] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City, DF, Mexico

[18] Univ Iowa, Mol Otolaryngol & Renal Res Labs, Iowa City, IA USA

[19] Columbia Univ, Med Ctr, Dept Med, Div Nephrol, New York, NY USA

[20] Ohio Kidney Associates, Columbus, OH USA

[21] Univ Toronto, Dept Med, Divs Nephrol, Toronto, ON, Canada

[22] Sorbonne Univ, Paris, France

[23] INSERM, UMR S1155, Paris, France

[24] Le Mans Hosp, Le Mans, France

[25] Univ Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands

[26] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[27] Juntendo Univ, Dept Nephrol, Tokyo, Japan

[28] Charles Univ Prague, Fac Med 1, Dept Nephrol, Prague, Czech Republic

[29] Charles Univ Prague, Gen Univ Hosp, Prague, Czech Republic

[30] Osped Pediat Bambino Gesu, Div Nephrol & Dialysis, Dept Pediat Subspecialties, Rome, Italy

[31] Radboud Univ Nijmegen Med Ctr, Dept Nephrol, Nijmegen, Netherlands

[32] MAGIC Evidence Ecosyst Fdn, Hamilton, ON, Canada

[33] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[34] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA, Australia

[35] Cochrane Kidney & Transplant, Sydney, NSW, Australia

[36] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia

[37] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada

[38] KDIGO, Brussels, Belgium

[39] Rhein Westfal Tech Hsch RWTH Aachen, Univ Hosp, Div Nephrol, Aachen, Germany

来源：

KIDNEY INTERNATIONAL | 2021年 / 100卷 / 04期

关键词：

AAV; ANCA; anti-GBM; C3; complement; evidence-based; FSGS; glomerular diseases; glomerulonephritis; guideline; IgA nephropathy; IgA vasculitis; infection-related glomerulonephritis; KDIGO; lupus nephritis; membranous nephropathy; minimal change disease; MPGN; nephrotic syndrome; systematic review;

D O I：

10.1016/j.kint.2021.05.015

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Glomerular Diseases is an update to the KDIGO 2012 guideline. The aim is to assist clinicians caring for individuals with glomerulonephritis (GN), both adults and children. The scope includes various glomerular diseases, including IgA nephropathy and IgA vasculitis, membranous nephropathy, nephrotic syndrome, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), infection-related GN, antineutrophil cytoplasmic antibody (ANCA) vasculitis, lupus nephritis, and anti-glomerular basement membrane antibody GN. In addition, this guideline will be the first to address the subtype of complement-mediated diseases. Each chapter follows the same format providing guidance related to diagnosis, prognosis, treatment, and special situations. The goal of the guideline is to generate a useful resource for clinicians and patients by providing actionable recommendations based on evidence syntheses, with useful infographics incorporating views from experts in the field. Another aim is to propose research recommendations for areas where there are gaps in knowledge. The guideline targets a broad global audience of clinicians treating GN while being mindful of implications for policy and cost. Development of this guideline update followed an explicit process whereby treatment approaches and guideline recommendations are based on systematic reviews of relevant studies, and appraisal of the quality of the evidence and the strength of recommendations followed the "Grading of Recommendations Assessment, Development and Evaluation" (GRADE) approach. Limitations of the evidence are discussed, with areas of future research also presented.

引用

页码：753 / 779

页数：27