Pharmacodynamics and pharmacokinetics of thiopental

被引:63
作者
Russo, H [1 ]
Bressolle, F
机构
[1] Fac Pharm Montpellier, Lab Pharmacocinet, F-34060 Montpellier, France
[2] CHU Montpellier, Montpellier, France
关键词
D O I
10.2165/00003088-199835020-00002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Thiopental is an ultra short-acting barbiturate which remains the standard against which other induction agents are judged; it is also indicated for the therapy of brain hypoxic-ischaemia injuries and status epilepticus. Aspects of drug distribution that govern the onset and end of drug effect have been intensively studied to determine which parameters (in patient characteristics, diseases and administration modalities) influence effective dose and concentrations in individual patients. Thiopental has been used as a reference for pharmacokinetic and/or pharmacodynamic models in the study of rapid and short acting effect drugs. In anaesthesiology the pharmacokinetics of thiopental are described as linear; when doses and duration of treatment increase, nonlinear pharmacokinetics occur because of the saturation and/or the induction of the metabolism.
引用
收藏
页码:95 / 134
页数:40
相关论文
共 235 条
[1]   PLASMA AND CEREBROSPINAL-FLUID BARBITURATE LEVELS DURING PROLONGED CONTINUOUS THIOPENTONE INFUSION [J].
AIREY, IL ;
SMITH, PA ;
STODDART, JC .
ANAESTHESIA, 1982, 37 (03) :328-331
[2]   THE VOLATILE ANESTHETICS, HALOTHANE, ENFLURANE AND ISOFLURANE, INFLUENCE THE DISTRIBUTION OF THIOPENTAL IN MAN DIFFERENTLY [J].
ALTMAYER, P ;
BUCH, U ;
HUTSCHENREUTER, K ;
BUCH, HP .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1987, 31 (08) :756-761
[3]  
ANDREASEN F, 1973, ACTA PHARMACOL TOX, V32, P417
[4]   CORTICAL EVOKED-POTENTIAL AND EXTRACELLULAR K+ AND H+ AT CRITICAL LEVELS OF BRAIN ISCHEMIA [J].
ASTRUP, J ;
SYMON, L ;
BRANSTON, NM ;
LASSEN, NA .
STROKE, 1977, 8 (01) :51-57
[5]   EFFECT OF SPEED OF INJECTION ON POTENCY OF ANESTHETIC INDUCTION-AGENTS [J].
AVELING, W ;
BRADSHAW, AD ;
CRANKSHAW, DP .
ANAESTHESIA AND INTENSIVE CARE, 1978, 6 (02) :116-119
[6]   THE RELATIONSHIP OF AGE TO THE PHARMACOKINETICS OF EARLY DRUG DISTRIBUTION - THE CONCURRENT DISPOSITION OF THIOPENTAL AND INDOCYANINE GREEN [J].
AVRAM, MJ ;
KREJCIE, TC ;
HENTHORN, TK .
ANESTHESIOLOGY, 1990, 72 (03) :403-411
[7]  
AVRAM MJ, 1993, ANESTH ANALG, V76, P10
[8]  
BALDEO W C, 1980, European Journal of Drug Metabolism and Pharmacokinetics, V5, P75
[9]   KINETICS OF THIOPENTONE IN RELATION TO THE SITE OF SAMPLING [J].
BARRATT, RL ;
GRAHAM, GG ;
TORDA, TA .
BRITISH JOURNAL OF ANAESTHESIA, 1984, 56 (12) :1385-1391
[10]   2 CASES OF UNTOWARD SEQUELAE ASSOCIATED WITH THIOPENTONE [J].
BAXTER, AD .
ANAESTHESIA, 1978, 33 (04) :349-351