Pigment Epithelium-Derived Factor Expression in Colorectal Cancer Patients

被引：14
作者：
Wagsater, Dick [2 ]
Lofgren, Sture [3 ]
Zar, Niklas [4 ]
Hugander, Anders [4 ]
Dimberg, Jan [1 ]
机构：
[1] Univ Coll Hlth Sci, Dept Nat Sci & Biomed, SE-55111 Jonkoping, Sweden
[2] Karolinska Inst, Dept Med, Atherosclerosis Res Unit, Stockholm, Sweden
[3] Ryhov Cty Hosp, Dept Clin Microbiol, Jonkoping, Sweden
[4] Ryhov Cty Hosp, Dept Surg, Jonkoping, Sweden
来源：
CANCER INVESTIGATION | 2010年 / 28卷 / 08期
关键词：
Pigment epithelium-derived factor; Polymorphism; Protein expression; Colorectal cancer; ENDOTHELIAL GROWTH-FACTOR; MACULAR DEGENERATION; MET72THR POLYMORPHISM; DOWN-REGULATION; FACTOR GENE; ANGIOGENESIS; PROGRESSION; PEDF; VEGF; IMPACT;
D O I：
10.3109/07357901003735675
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis and has been proposed to be a tumor suppressor in a variety of tumors. Limited reports exist of PEDF in colorectal cancer (CRC). We noted a 55% lower plasma level (p < .001) of PEDF in the CRC patient group (1.6 mu g/mL) than in of a healthy control group (3.6 mu g/mL). A single nucleotide polymorphism (rs1136287, T>C) was screened. In the control group, the CC genotype showed 30% lower PEDF plasma levels compared with the TT genotype (p < .01), whereas the CRC patients failed to show any association regarding these genotypes.
引用
收藏
页码：872 / 877
页数：6
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