Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach

被引：31

作者：

Balakrishnan, Biju ^{[1
,2
]}

Liang, Qi ^{[1
,3
]}

Fenix, Kevin ^{[2
,4
]}

Tamang, Bunu ^{[1
]}

Hauben, Ehud ^{[2
,4
,5
]}

Ma, Linlin ^{[6
]}

Zhang, Wei ^{[1
]}

机构：

[1] Flinders Univ S Australia, Coll Med & Publ Hlth, Ctr Marine Bioprod Dev, Adelaide, SA 5042, Australia

[2] Basil Hetzel Inst Translat Hlth Res, Adelaide, SA 5011, Australia

[3] Shanxi Univ Tradit Chinese Med, Taiyuan 030600, Peoples R China

[4] Univ Adelaide, Adelaide Med Sch, Fac Hlth & Med Sci, Discipline Surg, Adelaide, SA 5000, Australia

[5] AusHeth Corp Pty Ltd, Adelaide, SA 5032, Australia

[6] Griffith Univ, Griffith Inst Drug Discovery, Brisbane, Qld 4111, Australia

来源：

NUTRIENTS | 2021年 / 13卷 / 08期

关键词：

Astragalus; Shiitake; Hengshan Astragalus Shiitake; cancer immunology; medicinal food; bioactive; LENTINULA-EDODES MYCELIA; HEPATOCELLULAR-CARCINOMA CELLS; GUT MICROBIOTA DYSBIOSIS; MEDICINAL MUSHROOM; CANCER CELLS; LUNG-CANCER; HERB POLYSACCHARIDES; IMMUNE-RESPONSES; INFLAMMATION; EXTRACT;

D O I：

10.3390/nu13082564

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Astragalus root (Huang Qi) and Shiitake mushrooms (Lentinus edodes) are both considered medicinal foods and are frequently used in traditional Chinese medicine due to their anticancer and immunomodulating properties. Here, the scientific literatures describing evidence for the anticancer and immunogenic properties of Shiitake and Astragalus were reviewed. Based on our experimental data, the potential to develop medicinal food with combined bioactivities was assessed using Shiitake mushrooms grown over Astragalus beds in a proprietary manufacturing process, as a novel cancer prevention approach. Notably, our data suggest that this new manufacturing process can result in transfer and increased bioavailability of Astragalus polysaccharides with therapeutic potential into edible Shiitake. Further research efforts are required to validate the therapeutic potential of this new Hengshan Astragalus Shiitake medicinal food.

引用

页数：16

共 108 条

[1] Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production [J].