Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women

被引:27
作者
Rivera-Paredez, Berenice [1 ]
Macias, Nayeli [2 ]
Martinez-Aguilar, Mayeli M. [3 ]
Hidalgo-Bravo, Alberto [4 ]
Flores, Mario [2 ]
Quezada-Sanchez, Amado D. [5 ]
Denova-Gutierrez, Edgar [2 ]
Cid, Miguel [6 ]
Martinez-Hernandez, Angelica [6 ]
Orozco, Lorena [6 ]
Quiterio, Manuel [7 ]
Flores, Yvonne N. [8 ,9 ,10 ]
Salmeron, Jorge [1 ,7 ]
Velazquez-Cruz, Rafael [3 ]
机构
[1] Univ Nacl Autonoma Mexico, Sch Med, Res Ctr Policies Populat & Hlth, Acad Unit Epidemiol Res, Mexico City 04510, DF, Mexico
[2] Natl Inst Publ Hlth INSP, Nutr & Hlth Res Ctr, Cuernavaca 62100, Morelos, Mexico
[3] Natl Inst Genom Med INMEGEN, Genom Bone Metab Lab, Mexico City 14610, DF, Mexico
[4] Natl Inst Rehabil, Dept Genet, Mexico City 14389, DF, Mexico
[5] Natl Inst Publ Hlth INSP, Ctr Evaluat & Surveys Res, Cuernavaca 62100, Morelos, Mexico
[6] Natl Inst Genom Med INMEGEN, Inmunogen & Metab Dis Lab, Mexico City 14610, DF, Mexico
[7] Natl Inst Publ Hlth INSP, Ctr Populat Hlth Res, Cuernavaca 62100, Morelos, Mexico
[8] Mexican Inst Social Secur, Epidemiol & Hlth Serv Res Unit, Cuernavaca 62000, Morelos, Mexico
[9] Univ Calif Los Angeles, Kaiser Permanente Ctr Hlth Equ, Fielding Sch Publ Hlth, Dept Hlth Policy & Management, Los Angeles, CA 90001 USA
[10] Jonsson Comprehens Canc Ctr, Los Angeles, CA 90001 USA
关键词
total 25(OH) vitamin D; genetic polymorphism; vitamin D-binding protein; vitamin D receptor; bone mineral density; Mexican-Mestizo; PHYSICAL-ACTIVITY QUESTIONNAIRE; SERUM 25-HYDROXYVITAMIN D; GENOME-WIDE ASSOCIATION; D-BINDING-PROTEIN; PARATHYROID-HORMONE; HEALTH; VARIANTS; VALIDITY; AGE; SUPPLEMENTATION;
D O I
10.3390/nu10091175
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Genome-wide association studies in people with European ancestry suggest that polymorphisms in genes involved in vitamin D (VD) metabolism have an effect on serum concentrations of 25-hydroxyvitamin D. However, nothing is known about these polymorphisms in populations with Amerindian ancestry. Our aim was to evaluate the association between genetic variants on the vitamin D receptor (VDR) and the vitamin D binding protein (GC) genes, involved in the VD pathway, and VD deficiency in 689 unrelated Mexican postmenopausal women. We also described the frequencies of these variants in 355 postmenopausal women from different ethnic groups. Based on our preliminary results of 400 unrelated Mexican postmenopausal women, three single nucleotide polymorphisms (SNPs) were selected for genotyping. The SNPs rs4516035 in VDR and rs2282679 in GC were associated with VD deficiency. Additionally, women who carried three risk alleles had a 3.67 times higher risk of suffering VD deficiency, compared to women with no risk alleles (p = 0.002). The rs4516035-C allele frequency in the Amerindian population was enriched in the South East region of Mexico. In contrast, the highest frequency of the rs2298850-C allele, a proxy for the tag SNP rs2282679, was observed in the South region. Our results indicate that genetic variants in VDR and GC genes are associated with VD deficiency in Mexican postmenopausal women. Moreover, an association was observed for the variants rs3794060 and rs4944957 of the DHCR7/NADSYN1 gene with osteopenia/osteoporosis.
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页数:19
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