Nonlinear compartmental model indistinguishability

被引：8

作者：

Chapman, MJ

Godfrey, KR

机构：

[1] COVENTRY UNIV,CONTROL THEORY & APPLICAT CTR,COVENTRY CV1 5FB,W MIDLANDS,ENGLAND

[2] UNIV WARWICK,DEPT ENGN,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND

来源：

AUTOMATICA | 1996年 / 32卷 / 03期

关键词：

compartmental models; indistinguishability; local state isomorphism theorem; Michaelis-Menten kinetics; nonlinear systems; state-space methods;

D O I：

10.1016/0005-1098(95)00152-2

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

A version of the local state isomorphism theorem is used to show how nonlinear model structures, within some specified class, can be tested for indistinguishability from some given structure via a suitable choice of their respective parameters. This theory is applied to a two-compartmental structure with an assumed Michaelis-Menten elimination from compartment 1. Models tested for indistinguishability include structures with Michaelis-Menten elimination from compartment 2 in addition to, or instead of, that from compartment 1.

引用

页码：419 / 422

页数：4

共 14 条

[1] A METHODOLOGY FOR COMPARTMENTAL MODEL INDISTINGUISHABILITY [J].