Sevoflurane-induced pica in female rats

被引：8

作者：

Yamamoto, Kouichi ^{[1
]}

Yamamoto, Emiri ^{[2
]}

Sugimoto, Toru ^{[1
]}

Sagakami, Takuya ^{[1
]}

Yamatodani, Atsushi ^{[3
]}

机构：

[1] Osaka Univ, Grad Sch Med, Div Hlth Sci, Dept Med Sci & Technol, 1-7 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Kaizuka City Hosp, Dept Anesthesiol, 3-10-20 Hori, Kaizuka, Osaka 5970015, Japan

[3] Osaka Univ, 1-7 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2016年 / 131卷 / 01期

关键词：

Anti-emetic drugs; Pica; Postoperative nausea and vomiting; CISPLATIN-INDUCED ACUTE; POSTOPERATIVE NAUSEA; RISK; ANESTHESIA; MOTILITY;

D O I：

10.1016/j.jphs.2016.03.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the effects of volatile anesthetics on pica, which can be used to assess nausea and vomiting in rats. We found that inhalation anesthesia with sevoflurane significantly induced pica in female but not male rats. Among the female rats, young rats (8 weeks old) were more susceptible to its induction than adult rats (20 weeks old) with ovariectomy or sham-surgery. Anti-emetic drugs that are used to prevent postoperative nausea and vomiting (PONV) inhibited the pica. These results suggest that sevoflurane-induced pica in young female rats has the potential to be an animal model of PONV in humans. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：68 / 71

页数：4

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