Advanced dose calculation algorithm in superficial brachytherapy - the impact of tissue inhomogeneity on treatment plan dosimetry

被引:3
作者
Szlag, Marta [1 ]
Kellas-Sleczko, Sylwia [2 ]
Wojcieszek, Piotr [2 ]
Stankiewicz, Magdalena [2 ]
Cholewka, Agnieszka [1 ]
Pruefer, Agnieszka [1 ]
Krzysztofiak, Tomasz [2 ]
Lelek, Piotr [2 ]
Stapor-Fudzinska, Malgorzata [1 ]
Slosarek, Krzysztof [1 ]
机构
[1] Maria Sklodowska Curie Natl Res Inst Oncol Gliwic, Treatment Planning Dept, Wybrzeze Armii Krajowej 15, PL-44102 Gliwice, Poland
[2] Maria Sklodowska Curie Natl Res Inst Oncol Gliwic, Brachytherapy Dept, Gliwice, Poland
关键词
skin brachytherapy; moulds; TG-186; model-based dose-calculation algorithms; TG-43; RECOMMENDATIONS;
D O I
10.5114/jcb.2021.106541
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Given tissue inhomogeneity and lack of backscatter media, superficial brachytherapy necessitates more accurate dosimetry than TG-43 formalism. However, the introduction of modern model-based dose calculation algorithms into clinical practice should be carefully evaluated. The aim of this work was to compare dose distributions calculated with TG-43 and advanced collapsed cone engine (ACE) algorithms for individual multi-catheter moulds, and investigate the impact of target size and the lack of bolus to differences between plans. Material and methods: Eleven treatment plans for individual mould multi-catheter high-dose-rate brachytherapy (IMM HDR) were selected for retrospective analysis. All treatment plans were initially calculated with TG-43 formula and re-calculated using ACE algorithm. Plan re-calculation with ACE was repeated for each plan in order to assess the impact of bolus. To evaluate differences between TG-43 and ACE dose distributions, dose-volume histogram (DVH) parameters for each ROI were compared. D-max (maximal point dose), D-0.1cc, and D-2cc were calculated for each risk's organ (OARs) and for external contour. For clinical target volume (CTV), D-98, D-90, D-50, CTV coverage (CTV-V-100), and dose delivered to reference point were compared between the plans. Results: A significantly lower values (p < 0.05) of CTV parameters were observed for treatment plans calculated with ACE algorithm comparing to TG-43. Further analysis showed that differences between CTV-V-100 for ACE and TG-43 plans depended on CTV volume. Dosimetric parameters for OARs were significantly lower in ACE plans than those of TG-43. Only D-2cc for external and D-0.1cc for both eye lenses in ACE plans were insignificantly different comparing to TG-43 plans. Conclusions: Results show that differences between dosimetric parameters are statistically significant. However, their clinical relevance is still undetermined. Careful re-evaluation of the clinical results based on long-term research on TG-43 is necessary to safely introduce modern algorithms to clinical practice.
引用
收藏
页码:1 / 6
页数:6
相关论文
共 13 条
  • [1] Report of the Task Group 186 on model-based dose calculation methods in brachytherapy beyond the TG-43 formalism: Current status and recommendations for clinical implementation
    Beaulieu, Luc
    Tedgren, Asa Carlsson
    Carrier, Jean-Francois
    Davis, Stephen D.
    Mourtada, Firas
    Rivard, Mark J.
    Thomson, Rowan M.
    Verhaegen, Frank
    Wareing, Todd A.
    Williamson, Jeffrey F.
    [J]. MEDICAL PHYSICS, 2012, 39 (10) : 6208 - 6236
  • [2] The validity of Acuros BV and TG-43 for high-dose-rate brachytherapy superficial mold treatments
    Boman, Eeva L.
    Satherley, Thomas W. S.
    Schleich, Nanette
    Paterson, Dean B.
    Greig, Lynne
    Louwe, Rob J. W.
    [J]. BRACHYTHERAPY, 2017, 16 (06) : 1280 - 1288
  • [3] Non-melanoma skin cancer treated with high-dose-rate brachytherapy: a review of literature
    Delishaj, Durim
    Rembielak, Agata
    Manfredi, Bruno
    Ursino, Stefano
    Pasqualetti, Francesco
    Laliscia, Concetta
    Orlandi, Francesca
    Morganti, Riccardo
    Fabrini, Maria Grazia
    Paiar, Fabiola
    [J]. JOURNAL OF CONTEMPORARY BRACHYTHERAPY, 2016, 8 (06) : 533 - 540
  • [4] Dose specification for 192Ir high dose rate brachytherapy in terms of dose-to-water-in-medium and dose-to-medium-in-medium
    Fonseca, Gabriel Paiva
    Tedgren, Asa Carlsson
    Reniers, Brigitte
    Nilsson, Josef
    Persson, Maria
    Yoriyaz, Helio
    Verhaegen, Frank
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 2015, 60 (11) : 4565 - 4579
  • [5] Limitations of the TG-43 formalism for skin high-dose-rate brachytherapy dose calculations
    Granero, Domingo
    Perez-Calatayud, Jose
    Vijande, Javier
    Ballester, Facundo
    Rivard, Mark J.
    [J]. MEDICAL PHYSICS, 2014, 41 (02)
  • [6] GEC-ESTRO ACROP recommendations in skin brachytherapy
    Guinot, Jose L.
    Rembielak, Agata
    Perez-Calatayud, Jose
    Rodriguez-Villalba, Silvia
    Skowronek, Janusz
    Tagliaferri, Luca
    Guix, Benjamin
    Gonzalez-Perez, Victor
    Valentini, Vincenzo
    Kovacs, Gyoergy
    [J]. RADIOTHERAPY AND ONCOLOGY, 2018, 126 (03) : 377 - 385
  • [7] Impact of heterogeneity-corrected dose calculation using a grid-based Boltzmann solver on breast and cervix cancer brachytherapy
    Hofbauer, Julia
    Kirisits, Christian
    Resch, Alexandra
    Xu, Yingjie
    Sturdza, Alina
    Potter, Richard
    Nesvacil, Nicole
    [J]. JOURNAL OF CONTEMPORARY BRACHYTHERAPY, 2016, 8 (02) : 143 - 149
  • [8] Clinical transition to model-based dose calculation algorithm: A retrospective analysis of high-dose-rate tandem and ring brachytherapy of the cervix
    Jacob, Dayee
    Lamberto, Melissa
    Lawrence, Lana DeSouza
    Mourtada, Firas
    [J]. BRACHYTHERAPY, 2017, 16 (03) : 624 - 629
  • [9] A generic TG-186 shielded applicator for commissioning model-based dose calculation algorithms for high-dose-rate 192Ir brachytherapy
    Ma, Yunzhi
    Vijande, Javier
    Ballester, Facundo
    Tedgren, Asa Carlsson
    Granero, Domingo
    Haworth, Annette
    Mourtada, Firas
    Fonseca, Gabriel Paiva
    Zourari, Kyveli
    Papagiannis, Panagiotis
    Rivard, Mark J.
    Siebert, Frank-Andre
    Sloboda, Ron S.
    Smith, Ryan
    Chamberland, Marc J. P.
    Thomson, Rowan M.
    Verhaegen, Frank
    Beaulieu, Luc
    [J]. MEDICAL PHYSICS, 2017, 44 (11) : 5961 - 5976
  • [10] Impact of Heterogeneity-Based Dose Calculation Using a Deterministic Grid-Based Boltzmann Equation Solver for Intracavitary Brachytherapy
    Mikell, Justin K.
    Klopp, Ann H.
    Gonzalez, Graciela M. N.
    Kisling, Kelly D.
    Price, Michael J.
    Berner, Paula A.
    Eifel, Patricia J.
    Mourtada, Firas
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 83 (03): : E417 - E422