Aspergillus calidoustus case series and review of the literature

被引：24

作者：

Seroy, Justin ^{[1
,5
]}

Antiporta, Philip ^{[1
,6
]}

Grim, Shellee A. ^{[1
,2
]}

Proia, Laurie A. ^{[3
]}

Singh, Kamaljit ^{[4
,7
]}

Clark, Nina M. ^{[1
]}

机构：

[1] Loyola Univ Med Ctr, Dept Internal Med, Div Infect Dis, Maywood, IL 60153 USA

[2] Univ Illinois, Dept Pharm Practice, Chicago, IL USA

[3] Rush Univ Med Ctr, Div Infect Dis, Dept Internal Med, Chicago, IL USA

[4] Rush Univ Med Ctr, Dept Pathol, Chicago, IL USA

[5] Banner Univ Med Ctr, Phoenix, AZ USA

[6] Roseland Community Hosp, Jackson Pk Hosp & Med Ctr, Chicago, IL USA

[7] NorthShore Univ HealthSyst, Evanston, IL USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2017年 / 19卷 / 05期

关键词：

Aspergillus calidoustus; Aspergillus ustus; fungal epidemiology; invasive aspergillosis; CELL TRANSPLANT RECIPIENTS; INVASIVE FUNGAL-INFECTIONS; USTUS INFECTION; CUTANEOUS INFECTION; VORICONAZOLE; PATIENT; SURVEILLANCE; PROPHYLAXIS; EMERGENCE;

D O I：

10.1111/tid.12755

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aspergillus calidoustus, previously classified as Aspergillus ustus, is an emerging pathogen in immunocompromised persons. We describe four recent cases of A. calidoustus and review 37 additional cases of A. calidoustus (n = 8) or A. ustus (n = 29) published through June 2016. Twenty (49%) cases occurred in patients with hematologic malignancy and/or receipt of hematopoietic cell transplantation, and 13 (32%) occurred in solid organ transplant recipients. Antifungal susceptibility was reported in 49% of cases and in 42% treatment failed. Overall mortality was 66% and, where reported, attributable mortality was 30%. A. calidoustus infection is associated with a high mortality rate and frequently displays in vitro antifungal resistance.

引用

页数：8

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