Recent advances in carbocupration of α-heterosubstituted alkynes

被引：52
作者：
Basheer, Ahmad
Marek, Ilan [1 ]
机构：
[1] Technion Israel Inst Technol, Mallat Family Lab Organ Chem, Schulich Fac Chem, IL-32000 Haifa, Israel
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 6卷
关键词：
alkynes; carbocupration; enamides; regioselectivity; stereoselectivity; syn-addition; vinylcopper; ynamides; ynol ether; VINYL COPPER REAGENTS; CARBONYL ALLYLATION REACTIONS; CATALYZED CONJUGATE ADDITION; DIVERSITY-ORIENTED SYNTHESIS; CHIRAL QUATERNARY CENTERS; AZA-CLAISEN REARRANGEMENT; STEREOSELECTIVE-SYNTHESIS; ORGANIC-SYNTHESIS; CARBOMETALATION REACTIONS; TETRASUBSTITUTED OLEFINS;
D O I：
10.3762/bjoc.6.77
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Carbocupration of alpha-heterosubstituted alkynes leads to the formation of stereodefined functionalized vinyl copper species as single isomer. Recent advances in the field show that a simple pre-association of the organometallic derivative with an additional polar functional group in the vicinity of the reaction center may completely change the stereochemical outcome of the reaction. Representative examples are given in this mini-review.
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页数：12
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