Biology and Models of the Blood-Brain Barrier

被引：90
作者：
Hajal, Cynthia [1 ]
Le Roi, Baptiste [2 ]
Kamm, Roger D. [1 ,3 ]
Maoz, Ben M. [2 ,4 ,5 ]
机构：
[1] MIT, Dept Mech Engn, Cambridge, MA 02139 USA
[2] Tel Aviv Univ, Dept Biomed Engn, IL-6997801 Tel Aviv, Israel
[3] MIT, Dept Biol Engn, Cambridge, MA 02139 USA
[4] Tel Aviv Univ, Sagol Sch Neurosci, IL-6997801 Tel Aviv, Israel
[5] Tel Aviv Univ, Ctr Nanosci & Nanotechnol, IL-6997801 Tel Aviv, Israel
来源：
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021 | 2021年 / 23卷
基金：
以色列科学基金会; 欧洲研究理事会; 美国国家科学基金会;
关键词：
blood-brain barrier; organ-on-a-chip; tissue engineering; self-assembly; organoids; neurological diseases; CENTRAL-NERVOUS-SYSTEM; ENDOTHELIAL-CELLS; IN-VITRO; ELECTRICAL-RESISTANCE; CAPILLARY PERICYTES; TISSUE-CULTURE; PERMEABILITY; DISEASE; ASTROCYTES; FLOW;
D O I：
10.1146/annurev-bioeng-082120-042814
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The blood-brain barrier (BBB) is one of the most selective endothelial barriers. An understanding of its cellular, morphological, and biological properties in health and disease is necessary to develop therapeutics that can be transported from blood to brain. In vivo models have provided some insight into these features and transport mechanisms adopted at the brain, yet they have failed as a robust platform for the translation of results into clinical outcomes. In this article, we provide a general overview of major BBB features and describe various models that have been designed to replicate this barrier and neurological pathologies linked with the BBB. We propose several key parameters and design characteristics that can be employed to engineer physiologically relevant models of the blood-brain interface and highlight the need for a consensus in the measurement of fundamental properties of this barrier.
引用
收藏
页码：359 / 384
页数：26
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