Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis

被引：25

作者：

Prieto-Castaneda, Alejandro ^{[1
]}

Garcia-Garrido, Fernando ^{[1
]}

Diaz-Norambuena, Carolina ^{[2
]}

Escriche-Navarro, Blanca ^{[3
,4
,5
]}

Garcia-Fernandez, Alba ^{[3
,5
,6
]}

Banuclos, Jorge ^{[2
]}

Rebollar, Esther ^{[7
]}

Garcia-Moreno, Inmaculada ^{[7
]}

Martinez-Manez, Ramon ^{[3
,4
,5
,6
]}

de la Moya, Santiago ^{[1
]}

Agarrabeitia, Antonia R. . ^{[1
,8
]}

Ortiz, Maria J. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Dept Quim Organ, Fac Ciencias Quim, Madrid 28040, Spain

[2] Univ Pais Vasco EHU, Dept Quim Fis, Bilbao 48080, Spain

[3] Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermeda, Valencia 46012, Spain

[4] Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, IIS La Fe, Valencia 46026, Spain

[5] Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Univ Politecn Valencia, Valencia 46026, Spain

[6] CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain

[7] CSIC, Dept Sistemas Baja Dimensionalidad Superficies &, Inst Quim Fis Rocasolano, Madrid 28006, Spain

[8] Univ Complutense Madrid, Secc Dept Quim Organ, Fac Opt & Optometria, Madrid 28037, Spain

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 20期

关键词：

RATIONAL DESIGN; PHOTOSENSITIZERS; DIMERS;

D O I：

10.1021/acs.orglett.2c01169

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprece-dented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.

引用

页码：3636 / 3641

页数：6

共 24 条

[21] Hetero Bodipy-dimers as heavy atom-free triplet photosensitizers showing a long-lived triplet excited state for triplet-triplet annihilation upconversion [J].

Wu, Wanhua ;

Cui, Xiaoneng ;

Zhao, Jianzhang .

CHEMICAL COMMUNICATIONS, 2013, 49 (79) :9009-9011

[22] α-/β-Formylated Boron-Dipyrrin (BODIPY) Dyes: Regioselective Syntheses and Photophysical Properties [J].

Yu, Changjiang ;

Jiao, Lijuan ;

Yin, Hao ;

Zhou, Jinyuan ;

Pang, Weidong ;

Wu, Yangchun ;

Wang, Zhaoyun ;

Yang, Gaosheng ;

Hao, Erhong .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 2011 (28) :5460-5468

[23] Activatable molecular agents for cancer theranostics [J].

Zhang, Jianjian ;

Ning, Lulu ;

Huang, Jiaguo ;

Zhang, Chi ;

Pu, Kanyi .

CHEMICAL SCIENCE, 2020, 11 (03) :618-630

[24] Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application [J].

Zhao, Xueze ;

Liu, Jiangping ;

Fan, Jiangli ;

Chao, Hui ;

Peng, Xiaojun .

CHEMICAL SOCIETY REVIEWS, 2021, 50 (06) :4185-4219

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