Recent advances in the medical use of silver complex

被引：124

作者：

Liang, Xiaoxia ^{[1
]}

Luan, Shangxian ^{[1
]}

Yin, Zhongqiong ^{[1
]}

He, Min ^{[1
]}

He, Changliang ^{[1
]}

Yin, Lizi ^{[1
]}

Zou, Yuanfeng ^{[1
]}

Yuan, Zhixiang ^{[1
]}

Li, Lixia ^{[1
]}

Song, Xu ^{[1
]}

Lv, Chen ^{[1
]}

Zhang, Wei ^{[1
]}

机构：

[1] Sichuan Agr Univ, Coll Vet Med, Nat Med Res Ctr, Chengdu 611130, Sichuan, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 157卷

关键词：

Silver complex; Antibacterial; Antifungal; Antitumor; HETEROCYCLIC CARBENE COMPLEXES; CARBENE-SILVER(I) ACETATE COMPLEXES; RAY CRYSTAL-STRUCTURE; IN-VITRO ANTITUMOR; STRUCTURAL-CHARACTERIZATION; ANTICANCER ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL; ACID; CYTOTOXICITY;

D O I：

10.1016/j.ejmech.2018.07.057

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Silver has been used for numerous medical conditions for centuries, however, most of the current clinical silver agents all have their own disadvantages limiting the clinical usefulness. Therefore, employing ligands that can strongly coordinate to the active Ag(I) ions is essential. In recent years, systematic discovery and development of silver complex yielded a large number of promising antibacterial, antifungal and anticancer compounds. They were primarily classified into five classes: Ag(I)-NHC complex, Ag(I)carboxylate complex, Ag(I)-N-ligand complex, Ag(I)-P-ligand complex and Ag(I)-mixed ligand complex. Most of them showed enhanced activities than their pro-ligands, and some even exhibited exciting biological results better than the first line treatments in clinic. This review focuses on the development, application and chemical synthesis of pharmaceutical active silver complexes. Then we discuss the application prospect and development of active silver complex. (C) 2018 Elsevier Masson SAS. All rights reserved.

引用

页码：62 / 80

页数：19

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